Cold-induced thermogenesis in humans.
Cold-induced thermogenesis in humans.
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DOI：
10.1038/ejcn.2016.223
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发表时间：
2017-03
影响因子：
4.7
通讯作者：
Chen KY
中科院分区：
文献类型：
--
作者：
Brychta RJ;Chen KY
吸热体温调节的一个基本特性是通过增加代谢来应对寒冷的环境温度，以维持稳定的核心体温。这一过程被称为冷致产热（CIT），早在1780年就被安托万·拉瓦锡（Antoine Lavoisier）在人体中进行了测量，但由于最近在成年人中“重新发现”了产热、冷激活的棕色脂肪组织（BAT），因此重新引起了人们的兴趣。在这篇综述中，我们总结了过去两个世纪中涉及CIT工作的一些重要发现，并重点介绍了一些关于这一主题的开创性研究。在这些研究中，报告的CIT有很大的变化范围，从0到280%高于基础代谢。我们确定并讨论了这种差异的几个潜在来源，包括方法学（测量设备、冷暴露温度和持续时间）和生物学（受试者群体的年龄和身体组成）差异。在测量CIT时应考虑这些因素，以便根据BAT或其他产热器官提高人体代谢的相对能力，更好地评估它们是否是对抗慢性正能量平衡的可行目标。
A basic property of endothermic thermoregulation is the ability to generate heat by increasing metabolism in response to cold ambient temperatures to maintain a stable core body temperature. This process, known as cold-induced thermogenesis (CIT), has been measured in humans as early as 1780 by Antoine Lavoisier, but has found renewed interest because of the recent 'rediscovery' of thermogenic, cold-activated brown adipose tissue (BAT) in adult humans. In this review, we summarize some of the key findings of the work involving CIT over the past two centuries and highlight some of the seminal studies focused on this topic. There has been a substantial range of variability in the reported CIT in these studies, from 0 to 280% above basal metabolism. We identify and discuss several potential sources of this variability, including both methodological (measurement device, cold exposure temperature and duration) and biological (age and body composition of subject population) discrepancies. These factors should be considered when measuring CIT going forward to better assess whether BAT or other thermogenic organs are viable targets to combat chronic positive energy balance based on their relative capacities to elevate human metabolism.
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DOI：
10.1111/nyas.12304
发表时间：
2013-01-01
期刊：
UNDERSTANDING ADIPOGENESIS AND FUNCTIONS OF BROWN FAT
影响因子：
--
作者：
Dulloo, Abdul G.
通讯作者：
Dulloo, Abdul G.
影响因子：
5.8
作者：
Chen, Kong Y.;Brychta, Robert J.;Celi, Francesco S.
通讯作者：
Celi, Francesco S.
影响因子：
7.7
作者：
Hanssen, Mark J. W.;van der Lans, Anouk A. J. J.;Lichtenbelt, Wouter D. van Marken
通讯作者：
Lichtenbelt, Wouter D. van Marken
影响因子：
5.5
作者：
CANNON, P;KEATINGE, WR
通讯作者：
KEATINGE, WR
影响因子：
3.3
作者：
CRAIG, AB;DVORAK, M
通讯作者：
DVORAK, M