Coexistence of osteoporosis and atherosclerosis in pheochromocytoma: new insights into its long-term management
Coexistence of osteoporosis and atherosclerosis in pheochromocytoma: new insights into its long-term management
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嗜铬细胞瘤中骨质疏松和动脉粥样硬化的共存：对其长期治疗的新见解
DOI：
10.1007/s00198-020-05527-5
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发表时间：
2020
影响因子：
4
通讯作者：
Ogawa Y.
中科院分区：
文献类型：
--
作者：
Yokomoto-Umakoshi M.;the Q-AND-A study group;Umakoshi H.;Ogata M.;Fukumoto T.;Matsuda Y.;Miyazawa T.;Sakamoto R.;Ogawa Y.
嗜铬细胞瘤患者常合并骨质疏松和动脉粥样硬化。在PHEO患者中，骨质疏松的存在可能预示动脉粥样硬化的存在，反之亦然。这些研究结果有影响的长期管理的嗜铬细胞瘤及其潜在的慢性并发症。IntroductionPheochromocytoma（PHEO），一种产生儿茶酚胺的肿瘤，往往是偶然发现的，它可能存在多年前被诊断。然而，长期暴露于过量的儿茶酚胺可能会引起慢性并发症，如骨质疏松症和动脉粥样硬化。我们旨在评估PHEO患者伴随的骨质疏松症和动脉粥样硬化。Methods 51例PHEO患者和51例非功能性肾上腺肿瘤患者的影像学比较椎骨骨折（VF），典型的骨质疏松性骨折和腹主动脉钙化（AAC）的患病率。有室颤者AAC患病率（58%）高于无室颤者（6%，p < 0.001）。在PHEO患者中，校正年龄和性别后，AAC与VF相关（比值比，1.53; 95%置信区间，1.07-2.46;p =0.003）。儿茶酚胺过量的程度与VF和AAC的存在相关（p= 0.007）。PHEO患者VF的患病率（37%）高于非功能性AT患者（12%，p = 0.005），但两组AAC的患病率相当（25%和19%，p = 0.636）。PHEO患者VF和AAC并存的频率（22%）高于无功能性AT患者（2%，p = 0.003.ConclusionThis study represents the first demonstration that osteoporosis and atherosclerosis often exists in patients with PHEO（22%，p = 0.003）.在PHEO患者中，骨质疏松的存在可能预示动脉粥样硬化的存在，反之亦然。这些发现对PHEO的长期管理及其潜在的慢性并发症具有重要意义。
SummaryOsteoporosis and atherosclerosis frequently coexist in patients with pheochromocytoma. The presence of osteoporosis may predict that of atherosclerosis and vice versa in patients with PHEO. These findings have implications for the long-term management of the pheochromocytoma and its potential chronic complications.IntroductionPheochromocytoma (PHEO), a catecholamine-producing tumor, is often found incidentally, and it may be present for years before it is diagnosed. However, long-term exposure to catecholamines excess may induce chronic complications, such as osteoporosis and atherosclerosis. We aimed to evaluate concomitant osteoporosis and atherosclerosis in patients with PHEO.MethodsFifty-one patients with PHEO and 51 patients with a non-functional adrenal tumor were compared radiographically for the prevalence of vertebral fracture (VF), a typical osteoporotic fracture, and abdominal aortic calcification (AAC).ResultsIn patients with PHEO, the prevalence of AAC was higher in those with VF (58%) than in those without (6%,p< 0.001). AAC was associated with VF after adjusting for age and sex (odds ratio, 1.53; 95% confidence interval, 1.07–2.46;p =0.003) in patients with PHEO. The degree of catecholamine excess correlated with the presence of VF and AAC (p= 0.007). The prevalence of VF was higher in patients with PHEO (37%) than those with non-functional AT (12%,p= 0.005), but the prevalence of AAC was comparable between the two groups (25% and 19%,p= 0.636). VF and AAC more frequently coexisted in patients with PHEO (22%) than in those with non-functional AT (2%,p= 0.003).ConclusionThis study represents the first demonstration that osteoporosis and atherosclerosis frequently coexist in patients with PHEO. The presence of osteoporosis may predict that of atherosclerosis and vice versa in patients with PHEO. These findings have implications for the long-term management of the PHEO and its potential chronic complications.
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DOI：
10.1016/j.biocel.2019.01.004
发表时间：
2019-03-01
影响因子：
4
作者：
de Lucia, Claudio;Piedepalumbo, Michela;Koch, Walter J.
通讯作者：
Koch, Walter J.
影响因子：
5.3
作者：
Kauppila, LI;Polak, JF;Wilson, PWF
通讯作者：
Wilson, PWF
肾上腺素通过 cAMP/蛋白激酶 A 信号通路增强骨形态发生蛋白信号传导，从而加速成骨细胞分化。
影响因子：
4.1
作者：
T. Uemura;Y. Ohta;Yoshihiro Nakao;Tomoya Manaka;Hiroaki Nakamura;K. Takaoka
通讯作者：
K. Takaoka
影响因子：
5.8
作者：
Lenders, Jacques W. M.;Duh, Quan-Yang;Young, William F., Jr.
通讯作者：
Young, William F., Jr.
与原发性高血压患者相比，嗜铬细胞瘤患者颈动脉内膜中层厚度增加
影响因子：
2.7
作者：
R. Holaj;T. Zelinka;D. Wichterle;O. Petrák;B. Štrauch;A. Vránková;B. Majtan;Jiří Spáčil;Jan Malik;J. Widimský
通讯作者：
J. Widimský