Contribution of early-life unpredictability to neuropsychiatric symptom patterns in adulthood.
Contribution of early-life unpredictability to neuropsychiatric symptom patterns in adulthood.
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DOI：
10.1002/da.23277
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发表时间：
2022-10
影响因子：
7.4
通讯作者：
Risbrough, Victoria B.
中科院分区：
文献类型：
--
作者：
Spadoni, Andrea D.;Vinograd, Meghan;Cuccurazzu, Bruna;Torres, Katy;Glynn, Laura M.;Davis, Elysia P.;Baram, Tallie Z.;Baker, Dewleen G.;Nievergelt, Caroline M.;Risbrough, Victoria B.
关键词：
最近对人类和实验动物的研究已经确定，支离破碎和不可预测的父母和环境信号是早期生活逆境的一个新来源。早期生活的不可预测性可能是影响大脑发育的一个基本发育因素，包括奖励和情感记忆回路，影响以后生活中精神病理学的风险。在这里，我们测试了一个假设，即自我报告的早期生活的不可预测性与成人临床人群的精神症状。使用新验证的儿童期不可预测性问卷，我们评估了156名创伤暴露成人的早期生活不可预测性，其中65%寻求情绪，焦虑和/或创伤后应激障碍（PTSD）症状的治疗。所有参与者都完成了创伤后应激障碍，抑郁和快感缺乏，焦虑，酒精使用和慢性疼痛的症状测量。确定了早期生活不可预测性与童年创伤的相对贡献以及与6个月内纵向结果的关联。独立于童年创伤的早期生活不可预测性与较高的抑郁、焦虑症状和快感缺乏显著相关，并且与随时间推移较高的总体症状评分相关。早期生活的不可预测性也与自杀意念有关，但与饮酒或疼痛症状无关。早期生活的不可预测性是一个独立的和一致的预测特定的成人精神症状，提供动力，研究其对发育中的大脑，促进精神病理学的风险的影响机制。
Recent studies in both human and experimental animals have identified fragmented and unpredictable parental and environmental signals as a novel source of early-life adversity. Early-life unpredictability may be a fundamental developmental factor that impacts brain development, including reward and emotional memory circuits, affecting the risk for psychopathology later in life. Here, we tested the hypothesis that self-reported early-life unpredictability is associated with psychiatric symptoms in adult clinical populations. Using the newly validated Questionnaire of Unpredictability in Childhood, we assessed early-life unpredictability in 156 trauma-exposed adults, of which 65% sought treatment for mood, anxiety, and/or posttraumatic stress disorder (PTSD) symptoms. All participants completed symptom measures of PTSD, depression and anhedonia, anxiety, alcohol use, and chronic pain. Relative contributions of early-life unpredictability versus childhood trauma and associations with longitudinal outcomes over a 6-month period were determined. Early-life unpredictability, independent of childhood trauma, was significantly associated with higher depression, anxiety symptoms, and anhedonia, and was related to higher overall symptom ratings across time. Early-life unpredictability was also associated with suicidal ideation, but not alcohol use or pain symptoms. Early-life unpredictability is an independent and consistent predictor of specific adult psychiatric symptoms, providing impetus for studying mechanisms of its effects on the developing brain that promote risk for psychopathology.
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影响因子：
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