Hippocampal dysfunction effects on context memory: possible etiology for posttraumatic stress disorder.
Hippocampal dysfunction effects on context memory: possible etiology for posttraumatic stress disorder.
复制标题
DOI：
10.1016/j.neuropharm.2011.04.029
复制
发表时间：
2012-02
影响因子：
4.7
通讯作者：
Risbrough VB
中科院分区：
文献类型：
--
作者：
Acheson DT;Gresack JE;Risbrough VB
海马体积减少和功能损伤是创伤后应激障碍（PTSD）影像学研究的可靠发现。然而，目前尚不清楚海马功能障碍是否以及如何导致PTSD的病因和维持。创伤后应激障碍患者通常被描述为对创伤提醒的恐惧反应，而在这些提示可以合理地预测危险的环境之外。动物研究表明，海马体需要形成和回忆上下文刺激和厌恶事件之间的联系。例如，海马体对记忆编码至关重要，在这种记忆中，多种线索的复杂配置与厌恶事件有关。相反，海马体不需要与离散线索联系。在动物实验中，如果构形记忆被破坏，使用离散线索联想的学习策略占主导地位。这些数据表明，在创伤期间，海马功能低下可能使机体倾向于形成多种简单的线索关联，从而增加了在这些线索可能存在的多种环境（或背景）中产生恐惧反应的机会。在这里，我们将检查临床和动物文献来支持海马功能障碍作为创伤后应激障碍病因的主要促成因素的理论，并讨论验证这些假设所需的未来研究。
Hippocampal volume reductions and functional impairments are reliable findings in post-traumatic stress disorder (PTSD) imaging studies. However, it is not clear if and how hippocampal dysfunction contributes to the etiology and maintenance of PTSD. Individuals with PTSD are often described as showing fear responses to trauma reminders outside of contexts in which these cues would reasonably predict danger. Animal studies suggest that the hippocampus is required to form and recall associations between contextual stimuli and aversive events. For example, the hippocampus is critical for encoding memories in which a complex configuration of multiple cues is associated with the aversive event. Conversely, the hippocampus is not required for associations with discrete cues. In animal studies, if configural memory is disrupted, learning strategies using discrete cue associations predominate. These data suggest poor hippocampal function could bias the organism towards forming multiple simple cue associations during trauma, thus increasing the chances of fear responses in multiple environments (or contexts) in which these cues may be present. Here we will examine clinical and animal literature to support a theory of hippocampal dysfunction as a primary contributory factor to the etiology of PTSD, and discuss future research required to test these hypotheses.
登录
查看更多内容
影响因子：
3.4
作者：
Baker DG;Nievergelt CM;Risbrough VB
通讯作者：
Risbrough VB
影响因子：
10.6
作者：
Brohawn, Kathryn Handwerger;Offringa, Reid;Shin, Lisa M.
通讯作者：
Shin, Lisa M.
影响因子：
3.7
作者：
Binder, E. B.;Kuenzel, H. E.;Holsboer, F.
通讯作者：
Holsboer, F.
影响因子：
2.7
作者：
Barrientos, RM;O'Reilly, RC;Rudy, JW
通讯作者：
Rudy, JW
影响因子：
4.1
作者：
Brewin, CR
通讯作者：
Brewin, CR