The developing brain structural and functional connectome fingerprint.
The developing brain structural and functional connectome fingerprint.
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DOI：
10.1016/j.dcn.2022.101117
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发表时间：
2022-06
影响因子：
4.7
通讯作者：
Batalle, Dafnis
中科院分区：
文献类型：
--
作者：
Ciarrusta, Judit;Christiaens, Daan;Fitzgibbon, Sean P.;Dimitrova, Ralica;Hutter, Jana;Hughes, Emer;Duff, Eugene;Price, Anthony N.;Cordero-Grande, Lucilio;Tournier, J. -Donald;Rueckert, Daniel;V. Hajnal, Joseph;Arichi, Tomoki;McAlonan, Grainne;Edwards, David;Batalle, Dafnis
在成熟的大脑中，大脑连接的结构和功能“指纹”可用于识别个体的独特性。然而，使特定大脑与其他大脑区分开来的特征是否在出生时就已经存在仍然未知。在这里，我们使用了来自早产新生儿发育中的人类连接组计划 (dHCP) 的神经影像数据，这些新生儿在围产期进行了两次扫描，以评估发育中的大脑指纹。我们发现，62% 的参与者可以根据后来的结构连接体与从早期时间点得出的初始连接矩阵的一致性来识别。相比之下，同一受试者在不同时间点的功能连接体之间的相似性较低。与功能连接组的自我相似性相比，只有 10% 的参与者表现出更大的自我相似性。这些结果表明，结构连接在生命早期更加稳定，并且可以代表个体潜在的连接组指纹：当新生儿必须快速获得新技能以适应新环境时，相对稳定的结构连接组似乎支持不断变化的功能连接组。大脑结构连接组可用于识别出生时的个体 功能连接不太稳定，不能用作指纹 首次扫描时的年龄和扫描之间的天数对相似性的影响 结构和功能相似性在中央沟中表现最接近 首次扫描时的年龄对顶叶功能相似性有显着影响
In the mature brain, structural and functional ‘fingerprints’ of brain connectivity can be used to identify the uniqueness of an individual. However, whether the characteristics that make a given brain distinguishable from others already exist at birth remains unknown. Here, we used neuroimaging data from the developing Human Connectome Project (dHCP) of preterm born neonates who were scanned twice during the perinatal period to assess the developing brain fingerprint. We found that 62% of the participants could be identified based on the congruence of the later structural connectome to the initial connectivity matrix derived from the earlier timepoint. In contrast, similarity between functional connectomes of the same subject at different time points was low. Only 10% of the participants showed greater self-similarity in comparison to self-to-other-similarity for the functional connectome. These results suggest that structural connectivity is more stable in early life and can represent a potential connectome fingerprint of the individual: a relatively stable structural connectome appears to support a changing functional connectome at a time when neonates must rapidly acquire new skills to adapt to their new environment. The brain structural connectome can be used to identify an individual at birth Functional connectivity is less stable and cannot be used as a fingerprint Age at first scan and days between scans impacts on similarity Structural and functional similarity appear closest in central sulcus Age at first scan significantly impacts on parietal functional similarity
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DOI：
10.1093/cercor/bhy050
发表时间：
2018-07-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Dall'Orso S;Steinweg J;Allievi AG;Edwards AD;Burdet E;Arichi T
通讯作者：
Arichi T
影响因子：
5.7
作者：
Batalle D;Hughes EJ;Zhang H;Tournier JD;Tusor N;Aljabar P;Wali L;Alexander DC;Hajnal JV;Nosarti C;Edwards AD;Counsell SJ
通讯作者：
Counsell SJ
早产儿大脑连接组学分析揭示功能网络分离的早期发展
影响因子：
3.7
作者：
Cao, Miao;He, Yong;Huang, Hao
通讯作者：
Huang, Hao
影响因子：
2.5
作者：
Anderson, AW;Marois, R;Ment, LR
通讯作者：
Ment, LR
DOI：
10.1093/cercor/bhv203
发表时间：
2016-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Allievi AG;Arichi T;Tusor N;Kimpton J;Arulkumaran S;Counsell SJ;Edwards AD;Burdet E
通讯作者：
Burdet E