Somatotopic Mapping of the Developing Sensorimotor Cortex in the Preterm Human Brain.
Somatotopic Mapping of the Developing Sensorimotor Cortex in the Preterm Human Brain.
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DOI：
10.1093/cercor/bhy050
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发表时间：
2018-07-01
期刊：
影响因子：
--
通讯作者：
Arichi T
中科院分区：
文献类型：
--
作者：
Dall'Orso S;Steinweg J;Allievi AG;Edwards AD;Burdet E;Arichi T
在成熟的哺乳动物大脑中，已知初级躯体感觉和运动皮质在空间上是有组织的，因此与特定身体部分相关的神经活动可以在躯体上映射到解剖上的“小人”上。这种组织创造了一种内在的身体表现，这是精确的运动控制、空间意识和社会互动的基础。虽然目前还不清楚这种组织是什么时候在人类身上发展起来的，但动物研究表明，它甚至可能在正常分娩之前就出现了。因此，我们使用功能磁共振成像和一套定制的机器人工具对35名健康早产儿的初级感觉运动皮质的体位组织进行了表征，这些早产儿的年龄从31+6周到36+3周。手腕、脚踝和嘴部的躯体感觉刺激引起的功能反应具有明显的空间组织，如典型的成熟小人地图所示。与脚踝相比，与腕部刺激相关的激活明显更大，并且更常见地涉及辅助运动区和同侧感觉运动皮质等额外区域。这些结果与早期对初级感觉运动皮质内躯体定位图的内在确定是一致的。这可能解释了为什么早产期该区域的获得性脑损伤不能通过皮质重组来补偿，因此可能导致长期的运动和感觉损伤。
In the mature mammalian brain, the primary somatosensory and motor cortices are known to be spatially organized such that neural activity relating to specific body parts can be somatopically mapped onto an anatomical “homunculus”. This organization creates an internal body representation which is fundamental for precise motor control, spatial awareness and social interaction. Although it is unknown when this organization develops in humans, animal studies suggest that it may emerge even before the time of normal birth. We therefore characterized the somatotopic organization of the primary sensorimotor cortices using functional MRI and a set of custom-made robotic tools in 35 healthy preterm infants aged from 31 + 6 to 36 + 3 weeks postmenstrual age. Functional responses induced by somatosensory stimulation of the wrists, ankles, and mouth had a distinct spatial organization as seen in the characteristic mature homunculus map. In comparison to the ankle, activation related to wrist stimulation was significantly larger and more commonly involved additional areas including the supplementary motor area and ipsilateral sensorimotor cortex. These results are in keeping with early intrinsic determination of a somatotopic map within the primary sensorimotor cortices. This may explain why acquired brain injury in this region during the preterm period cannot be compensated for by cortical reorganization and therefore can lead to long-lasting motor and sensory impairment.
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影响因子：
5.7
作者：
Arichi, Tomoki;Fagiolo, Gianlorenzo;Varela, Marta;Melendez-Calderon, Alejandro;Allievi, Alessandro;Merchant, Nazakat;Tusor, Nora;Counsell, Serena J.;Burdet, Etienne;Beckmann, Christian F.;Edwards, A. David
通讯作者：
Edwards, A. David
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
64.8
作者：
Florence, SL;Jain, N;Kaas, JH
通讯作者：
Kaas, JH
影响因子：
64.8
作者：
Khazipov, R;Sirota, A;Buzsáki, G
通讯作者：
Buzsáki, G
DOI：
10.1093/cercor/bhv203
发表时间：
2016-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Allievi AG;Arichi T;Tusor N;Kimpton J;Arulkumaran S;Counsell SJ;Edwards AD;Burdet E
通讯作者：
Burdet E