The Unforeseen Non-Coding RNAs in Head and Neck Cancer.
The Unforeseen Non-Coding RNAs in Head and Neck Cancer.
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DOI：
10.3390/genes9030134
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发表时间：
2018-03-01
期刊：
影响因子：
3.5
通讯作者：
Berindan-Neagoe I
中科院分区：
文献类型：
--
作者：
Irimie AI;Zimta AA;Ciocan C;Mehterov N;Dudea D;Braicu C;Berindan-Neagoe I
以前被忽视的非编码rna （ncRNAs）已经成为许多研究的主题。然而，在ncrna得到的考虑数量上存在不平衡。一些转录本，如microRNAs （miRNAs）或小干扰RNA （sirna）已经获得了很多关注，但有必要研究其他“RNA之谜”。这些可以提供对正常和病理细胞行为的更完整的看法。其他ncRNA种类的研究较少，要么是因为它们最近才被发现，如稳定的intronic sequence RNA （sisRNA）、YRNA、miRNA-offset RNA （moRNA）、端粒酶RNA组分（TERC）、天然反义转录物（NAT）、转录超保守区（T-UCR）和假基因转录物，要么是因为它们在很大程度上仍被视为与发病机制无关的非编码转录物。此外，有些仍然被认为是管家rna，例如小核仁rna （small nucleolar rna, snoRNAs）和TERC。本文综述了鲜为人知的ncrna在头颈癌中的生物学发生、作用机制和潜在作用，并重点介绍了这一特殊癌症类型的研究进展。
Previously ignored non-coding RNAs (ncRNAs) have become the subject of many studies. However, there is an imbalance in the amount of consideration that ncRNAs are receiving. Some transcripts such as microRNAs (miRNAs) or small interfering RNAs (siRNAs) have gained much attention, but it is necessary to investigate other “pieces of the RNA puzzle”. These can offer a more complete view over normal and pathological cell behavior. The other ncRNA species are less studied, either due to their recent discovery, such as stable intronic sequence RNA (sisRNA), YRNA, miRNA-offset RNAs (moRNA), telomerase RNA component (TERC), natural antisense transcript (NAT), transcribed ultraconserved regions (T-UCR), and pseudogene transcript, or because they are still largely seen as non-coding transcripts with no relevance to pathogenesis. Moreover, some are still considered housekeeping RNAs, for instance small nucleolar RNAs (snoRNAs) and TERC. Our review summarizes the biogenesis, mechanism of action and potential role of less known ncRNAs in head and neck cancer, with a particular focus on the installment and progress for this particular cancer type.
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DOI：
10.3322/caac.21244
发表时间：
2014-09
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Berindan-Neagoe I;Monroig Pdel C;Pasculli B;Calin GA
通讯作者：
Calin GA
影响因子：
4.2
作者：
Chiba M;Kimura M;Asari S
通讯作者：
Asari S
影响因子：
9.2
作者：
Boscolo-Rizzo, Paolo;Da Mosto, Maria Cristina;Rampazzo, Enrica;Giunco, Silvia;Del Mistro, Annarosa;Menegaldo, Anna;Baboci, Lorena;Mantovani, Monica;Tirelli, Giancarlo;De Rossi, Anita
通讯作者：
De Rossi, Anita
影响因子：
--
作者：
Davanian H;Balasiddaiah A;Heymann R;Sundström M;Redenström P;Silfverberg M;Brodin D;Sällberg M;Lindskog S;Kruger Weiner C;Chen M
通讯作者：
Chen M
影响因子：
64.8
作者：
CRICK, F
通讯作者：
CRICK, F