Associations of adiposity measurements with thyroid nodules in Chinese children living in iodine-sufficient areas: an observational study.
Associations of adiposity measurements with thyroid nodules in Chinese children living in iodine-sufficient areas: an observational study.
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生活在碘充足地区的中国儿童肥胖测量与甲状腺结节的关联：一项观察性研究
DOI：
10.1136/bmjopen-2017-016706
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发表时间：
2017-10-30
期刊：
影响因子：
2.9
通讯作者：
Jiang Q
中科院分区：
文献类型：
--
作者：
Wang N;Fang H;Fu C;Huang P;Su M;Jiang F;Zhao Q;Chen Y;Jiang Q
肥胖与甲状腺结节风险增加有关，主要发生在成年人;然而，儿童肥胖与甲状腺结节风险增加相关的证据有限。本研究的目的是调查碘供应充足地区儿童肥胖与甲状腺结节的关系。背景和参与者我们在2014年对生活在中国东海岸的1403名中国儿童进行了一项横断面研究。测量身高、体重、腰围、臀围，计算体重指数（BMI）、体表面积（BSA）和腰臀比（WHR）。进行甲状腺超声检查以评估甲状腺体积和结节。结果以BMI为标准，超重儿童255人（18.17%），肥胖儿童174人（12.40%）。甲状腺结节检出率为18.46%，年龄和性别差异不大。与正常体重儿童相比，肥胖儿童患甲状腺单发结节（OR 2.07（95%CI 1.16 ~ 3.71））和多发结节（OR 1.67（95%CI 1.03 ~ 2.70））的风险显著增高。通过腰围和BSA测量的肥胖与甲状腺结节有类似的相关性，但WHR没有。食用碘盐和非碘盐的儿童之间的相关性没有显着差异。结论这些发现进一步证明儿童肥胖与甲状腺结节的风险有关。
Objectives Obesity has been found to be associated with an elevated risk of thyroid nodule(s), mainly in adults; however, evidence for this association in children was limited. The objective of this study was to investigate the association of adiposity and thyroid nodule(s) in children living in iodine-sufficiency areas. Setting and participants We conducted a cross-sectional study of 1403 Chinese children living in the East Coast of China in 2014. Outcome measures Anthropometric measures including height, weight and waist and hip circumferences were taken, and body mass index (BMI), body surface area (BSA) and waist–hip ratio (WHR) were then calculated. Thyroid ultrasonography was performed to assess thyroid volume and nodules. Results Based on BMI, 255 (18.17%) children were overweight and 174 (12.40%) were obese. Thyroid nodule(s) was detected in 18.46% of all participants and showed little age and sex variations. As compared with normal-weight children, obese children experienced significantly higher risks for solitary (OR 2.07 (95% CI 1.16 to 3.71)) and multiple (OR 1.67 (95% CI 1.03 to 2.70)) thyroid nodules. Similar associations with thyroid nodule(s) were observed with adiposity measured by waist circumference and BSA, but not WHR. There were no notable differences in the associations between children consuming iodised and non-iodised salt. Conclusions These findings provide further evidence that childhood obesity is associated with the risk for thyroid nodule(s).
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影响因子：
3.7
作者：
Hayashida N;Imaizumi M;Shimura H;Okubo N;Asari Y;Nigawara T;Midorikawa S;Kotani K;Nakaji S;Otsuru A;Akamizu T;Kitaoka M;Suzuki S;Taniguchi N;Yamashita S;Takamura N;Investigation Committee for the Proportion of Thyroid Ultrasound Findings
通讯作者：
Investigation Committee for the Proportion of Thyroid Ultrasound Findings
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作者：
Katzmarzyk, P. T.;Bouchard, C.
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Bouchard, C.