Measurement properties of three assessments of burden used in atopic dermatitis in adults.
Measurement properties of three assessments of burden used in atopic dermatitis in adults.
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DOI：
10.1111/bjd.17243
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发表时间：
2019-05
期刊：
影响因子：
--
通讯作者：
Silverberg JI
中科院分区：
文献类型：
--
作者：
Patel KR;Singam V;Vakharia PP;Chopra R;Sacotte R;Patel N;Immaneni S;Kantor R;Hsu DY;Silverberg JI
标准化的生活质量(QOL)评估可以提供重要的临床相关信息。目前AD患者的生活质量评估缺乏标准化。我们试图确定皮肤科生活质量指数(DLQI)、ItchyQOL和5维(5-D)瘙痒量表用于评估成人AD负担的内容效度、结构效度、内部一致性、不同报告、反应性、地板或天花板效应以及可行性，并比较它们的表现。对340例成人阿尔茨海默病患者进行了自填式问卷调查和皮肤科检查。DLQI、ItchyQOL和5-D均具有较好的内容效度。DLQI、平均ItchyQOL和5-D瘙痒均与AD症状频度(POEM)、瘙痒强度(NRS-瘙痒)呈强相关，与AD严重程度(EASI和SCORAD)呈中等相关(Spearman相关，均P<；0.0001)。DLQI和5-D瘙痒表现出良好的内部一致性(Cronbach‘s Alpha：0.88和0.82)，尽管ItchyQOL似乎有几个多余的项目(Alpha=0.96)。在DLQI、ItchyQOL和5-D瘙痒中，发现年龄、性别和/或种族/民族的多个项目具有一致和非一致的差异项目功能。DLQI、ItchyQOL和5-D瘙痒评分都表现出了反应性，尽管ItchyQOL表现出了最大的反应性。总分没有下限或天花板效应。完成DLQI、ItchyQOL和5-D瘙痒的中位时间为2分钟。DLQI、ItchyQOL和5-D瘙痒量表在成人AD的评估中均表现出良好的内容效度和结构效度及反应性，可用于临床试验和实践。
Standardized quality of life (QOL) assessments can provide important and clinically relevant information. There is currently a lack of standardization in QOL assessments used in AD. We sought to determine the content validity, construct validity, internal consistency, differential reporting, responsiveness, floor or ceiling effects, and feasibility of Dermatology Life Quality Index (DLQI), ItchyQOL and 5-dimensions (5-D) itch scales for assessing burden of AD in adults and compare their performance. Self-administered questionnaires and skin-examination were performed in 340 adults with AD in a dermatology practice setting. DLQI, ItchyQOL and 5-D all had good content validity. DLQI, mean ItchyQOL and 5-D itch all had strong correlations with frequency of AD symptoms (POEM), intensity of itch (NRS-itch), and moderate correlations with AD severity (EASI and SCORAD) (Spearman correlations, P<0.0001 for all). DLQI and 5-D itch showed good internal consistency (Cronbach’s alpha: 0.88 and 0.82), though ItchyQOL appeared to have several redundant items (alpha=0.96). Uniform and non-uniform differential item functioning by age, sex and/or race/ethnicity was found for multiple items in DLQI, ItchyQOL and 5-D itch. DLQI, ItchyQOL and 5-D itch scores all demonstrated responsiveness, though ItchyQOL demonstrated the greatest responsiveness. There were no floor or ceiling effects for total scores. The median time to completion of DLQI, ItchyQOL and 5-D itch was 2 minutes. DLQI, ItchyQOL and 5-D itch scales all showed good content and construct validity, and responsiveness in the assessment of AD in adults, and were feasible for use in clinical trials and practice.
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影响因子：
6.5
作者：
Chren, MM;Lasek, RJ;Zyzanski, SJ
通讯作者：
Zyzanski, SJ
影响因子：
--
作者：
Charman, CR;Venn, AJ;Williams, HC
通讯作者：
Williams, HC
影响因子：
13.8
作者：
Finlay, AY
通讯作者：
Finlay, AY
影响因子：
10.3
作者：
Holm, EA;Wulf, HC;Jemec, GBE
通讯作者：
Jemec, GBE
影响因子：
13.8
作者：
Hahn, HB;Melfi, CA;Farmer, ER
通讯作者：
Farmer, ER