Metabolomic signature of brain cancer.
Metabolomic signature of brain cancer.
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DOI：
10.1002/mc.22694
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发表时间：
2017-11
影响因子：
4.6
通讯作者：
Tiziani S
中科院分区：
文献类型：
--
作者：
Pandey R;Caflisch L;Lodi A;Brenner AJ;Tiziani S
尽管手术和辅助治疗取得了进展，但脑肿瘤仍然是成人和儿童癌症相关死亡率和发病率的主要原因之一。胶质瘤约占所有脑肿瘤的60%，表现出不同程度的恶性。由于预后不佳和治疗方法有限，它们难以治疗。代谢组学是内源性和外源性小分子的非靶向和靶向分析，表征个体的表型。这种新兴的“组学”科学提供了细胞活动的功能读数，对理解包括脑肿瘤生物学在内的癌症生物学做出了巨大贡献。代谢物作为生化活性的直接标志，信息量很大；因此，代谢物谱分析已成为临床诊断和预后的一种很有前途的方法。代谢改变被认为是监测疾病进展、治疗和揭示有效治疗干预的新分子靶点的关键标志之一。利用最新的高通量分析技术，如核磁共振光谱和质谱，代谢组学现在是精准医学和药物发现的一个有前途的领域。在本报告中，我们回顾了代谢组学和体内代谢谱在成人胶质瘤和儿科脑肿瘤中的应用。讨论了高分辨率核磁共振、体内磁共振光谱成像和高、低分辨率质谱等分析平台。此外，代谢研究在胶质瘤治疗新策略开发中的相关性进行了综述。
Despite advances in surgery and adjuvant therapy, brain tumours represent one of the leading causes of cancer-related mortality and morbidity in both adults and children. Gliomas constitute about 60% of all cerebral tumours, showing varying degrees of malignancy. They are difficult to treat due to dismal prognosis and limited therapeutics. Metabolomics is the untargeted and targeted analyses of endogenous and exogenous small molecules, which characterizes the phenotype of an individual. This emerging “omics” science provides functional readouts of cellular activity that contribute greatly to the understanding of cancer biology including brain tumour biology. Metabolites are highly informative as a direct signature of biochemical activity; therefore, metabolite profiling has become a promising approach for clinical diagnostics and prognostics. The metabolic alterations are well-recognized as one of the key hallmarks in monitoring disease progression, therapy and revealing new molecular targets for effective therapeutic intervention. Taking advantage of the latest high-throughput analytical technologies, i.e. nuclear magnetic resonance spectroscopy and mass spectrometry, metabolomics is now a promising field for precision medicine and drug discovery. In the present report, we review the application of metabolomics and in vivo metabolic profiling in the context of adult gliomas and paediatric brain tumours. Analytical platforms such as high-resolution nuclear magnetic resonance, in vivo magnetic resonance spectroscopic imaging and high- and low-resolution mass spectrometry are discussed. Moreover, the relevance of metabolic studies in the development of new therapeutic strategies for treatment of gliomas are reviewed.
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DOI：
10.1016/s0378-4347(01)00081-0
发表时间：
2001-06-05
影响因子：
3
作者：
Camera, E;Rinaldi, M;Fanali, S
通讯作者：
Fanali, S
DOI：
10.1016/s0021-9673(00)83064-2
发表时间：
1981-01-01
期刊：
JOURNAL OF CHROMATOGRAPHY
影响因子：
--
作者：
CHAUHAN, J;DARBRE, A
通讯作者：
DARBRE, A
影响因子：
--
作者：
Björkblom B;Wibom C;Jonsson P;Mörén L;Andersson U;Johannesen TB;Langseth H;Antti H;Melin B
通讯作者：
Melin B
影响因子：
6.1
作者：
Cavazos DA;Brenner AJ
通讯作者：
Brenner AJ
影响因子：
11.5
作者：
Astrakas, LG;Zurakowski, D;Black, PM
通讯作者：
Black, PM