Nut consumption and risk of pancreatic cancer in women.
Nut consumption and risk of pancreatic cancer in women.
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DOI：
10.1038/bjc.2013.665
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发表时间：
2013-11-26
影响因子：
8.8
通讯作者：
Fuchs CS
中科院分区：
文献类型：
--
作者：
Bao Y;Hu FB;Giovannucci EL;Wolpin BM;Stampfer MJ;Willett WC;Fuchs CS
增加坚果摄入量与糖尿病风险降低有关，糖尿病是胰腺癌的风险因素。我们在护士健康研究中前瞻性地跟踪了75680名妇女，并检查了坚果消费与胰腺癌风险之间的关系。有癌症病史的参与者被排除在外。在基线时评估坚果消费量，每2至4年更新一次。使用考克斯比例风险模型估计相对风险（RR）和95%置信区间（95% CI）。我们记录了466例胰腺癌病例。在调整了年龄，身高，吸烟，体力活动和总能量摄入量后，与那些基本上不吃坚果的人相比，每周食用28克（1盎司）坚果102次的女性患胰腺癌的风险显著降低（RR，0.65; 95%CI，0.47-0.92;趋势P =0.007）。进一步校正体重指数（BMI）和糖尿病史后，结果没有明显变化（RR，0.68; 95%CI，0.48-0.95;趋势P =0.01）。在BMI、体力活动、吸烟和红肉、水果和蔬菜摄入量定义的分层中，负相关持续存在。在这个大型前瞻性队列研究中，频繁食用坚果与胰腺癌风险呈负相关，与胰腺癌的其他潜在风险因素无关。
Increasing nut intake has been associated with reduced risk of diabetes mellitus, which is a risk factor for pancreatic cancer. We prospectively followed 75 680 women in the Nurses' Health Study, and examined the association between nut consumption and pancreatic cancer risk. Participants with a previous history of cancer were excluded. Nut consumption was assessed at baseline and updated every 2 to 4 years. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models. We documented 466 incident cases of pancreatic cancer. After adjusting for age, height, smoking, physical activity, and total energy intake, women who consumed a 28-g (1 oz) serving size of nuts ⩾2 times per week experienced a significantly lower risk of pancreatic cancer (RR, 0.65; 95% CI, 0.47–0.92; P for trend=0.007) when compared with those who largely abstained from nuts. The results did not appreciably change after further adjustment for body mass index (BMI) and history of diabetes mellitus (RR, 0.68; 95% CI, 0.48–0.95; P for trend=0.01). The inverse association persisted within strata defined by BMI, physical activity, smoking, and intakes of red meat, fruits, and vegetables. Frequent nut consumption is inversely associated with risk of pancreatic cancer in this large prospective cohort of women, independent of other potential risk factors for pancreatic cancer.
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影响因子：
8.8
作者：
Bosetti C;Turati F;Dal Pont A;Ferraroni M;Polesel J;Negri E;Serraino D;Talamini R;La Vecchia C;Zeegers MP
通讯作者：
Zeegers MP
影响因子：
4.5
作者：
O'Neil, Carol E.;Keast, Debra R.;Fulgoni, Victor L., III
通讯作者：
Fulgoni, Victor L., III
影响因子：
3.8
作者：
Michaud, Dominique S.;Wolpin, Brian;Fuchs, Charles S.
通讯作者：
Fuchs, Charles S.
影响因子：
4.2
作者：
Jenkins, David J. A.;Kendall, Cyril W. C.;Rao, A. Venket
通讯作者：
Rao, A. Venket
影响因子：
6.4
作者：
Molina-Montes, Esther;Wark, Petra A.;Bueno-de-Mesquita, Bas
通讯作者：
Bueno-de-Mesquita, Bas