The role of Mediterranean diet on the risk of pancreatic cancer.
The role of Mediterranean diet on the risk of pancreatic cancer.
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DOI：
10.1038/bjc.2013.345
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发表时间：
2013-09-03
影响因子：
8.8
通讯作者：
Zeegers MP
中科院分区：
文献类型：
--
作者：
Bosetti C;Turati F;Dal Pont A;Ferraroni M;Polesel J;Negri E;Serraino D;Talamini R;La Vecchia C;Zeegers MP
地中海饮食已被证明对各种肿瘤有有益的作用，但胰腺癌的数据很少。我们分析了1983年至2008年在意大利进行的两项病例对照研究的数据，分别包括362例和326例胰腺癌病例以及1552例和652例医院对照。地中海饮食评分（MDS）总结了地中海饮食的主要特征，分别用于两项研究和总体研究。在第二项研究中，仅应用了地中海饮食模式坚持指数（MDP）和地中海饮食习惯指数（MAI）。增加分数水平的比值比（OR）（即，增加的依从性）使用多元逻辑回归模型进行估计。MDS评分≥ 6与<3的比值比在第一项研究中为0.57（95%置信区间（CI）0.34-0.95），在第二项研究中为0.51（95% CI 0.29-0.92），总体为0.48（95% CI 0.35-0.67）。MDP和MAI也观察到风险降低的趋势，MDP最高与最低五分位数的OR为0.44（95% CI 0.27-0.73），MAI为0.68（95% CI 0.42-1.11）。研究结果在年龄、性别、教育、体重指数、饮酒、吸烟和糖尿病等方面都是一致的。我们的研究提供了证据表明，测量地中海饮食依从性的优先定义分数与胰腺癌风险有利相关。
The Mediterranean diet has been shown to have a beneficial role on various neoplasms, but data are scanty on pancreatic cancer. We analysed data from two case–control studies conducted in Italy between 1983 and 2008, including 362 and 326 pancreatic cancer cases and 1552 and 652 hospital-controls, respectively. A Mediterranean Diet Score (MDS) summarising major characteristics of the Mediterranean diet was used in the two studies separately and overall. Two further scores of adherence to the Mediterranean diet were applied in the second study only, the Mediterranean Dietary Pattern Adherence Index (MDP) and the Mediterranean Adequacy Index (MAI). Odds ratios (ORs) for increasing levels of the scores (i.e., increasing adherence) were estimated using multiple logistic regression models. Odds ratio for a MDS score ⩾6 compared with <3 was 0.57 (95% confidence interval (CI) 0.34–0.95) in the first study, 0.51 (95% CI 0.29–0.92) in the second study, and 0.48 (95% CI 0.35–0.67) overall. A trend of decreasing risk was observed also for the MDP and MAI the ORs for the highest vs the lowest quintile being 0.44 (95% CI 0.27–0.73) for MDP and 0.68 (95% CI 0.42–1.11) for the MAI. The results were consistent across strata of age, sex, education, body mass index, alcohol drinking, tobacco smoking, and diabetes. Our study provides evidence that a priori-defined scores measuring adherence to the Mediterranean diet are favourably associated with pancreatic cancer risk.
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