Predictors of 30-year mortality in depressed and comparison samples.
Predictors of 30-year mortality in depressed and comparison samples.
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抑郁样本和对照样本 30 年死亡率的预测因子。
DOI：
10.1016/j.jad.2014.04.031
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发表时间：
2014
影响因子：
6.6
通讯作者：
R. Cronkite
中科院分区：
文献类型：
--
作者：
A. Finlay;Elizabeth M Oliva;C. Timko;R. Moos;R. Cronkite
背景虽然较高的抑郁率和较低的社会行为（即社会支持和活动）和体力活动率与死亡率相关，但这些因素的独立贡献需要检查。方法使用了 848 名个体（55% 女性）的前瞻性样本；一半在基线时患有临床抑郁症；另一半包括与人口普查区、性别和婚姻状况相匹配的比较样本。使用缺失数据的多重插补和 Cox 比例风险回归，控制人口因素和健康风险因素，将抑郁症状、社会行为和体力活动作为 30 年期间死亡率的时变预测因子进行检查。结果到研究结束时，抑郁样本中的 137 名个体和比较样本中的 99 名个体已经死亡。尽管抑郁症样本的死亡率较高，但在控制人口、健康危险因素、社会行为和体力活动后，抑郁症样本和对照样本之间的死亡率没有显着差异。在抑郁症样本的参与者中，减少社会活动参与与较高的死亡风险显着相关。局限性没有评估活动的频率和强度，除死亡率外的所有数据都是自我报告。结论通过活动促进社会参与可能有望延迟抑郁症个体的死亡。讨论了促进社会参与的潜在方法以及未来研究中应考虑的积极情绪等因素。
BackgroundAlthough higher rates of depression and lower rates of social behaviors (i.e., social support and activities) and physical activities are associated with mortality, the independent contribution of each of these factors needs examination.MethodsA prospective sample of 848 individuals (55% female) was used; half were clinically depressed at baseline; the other half comprised a comparison sample matched on census tract, gender, and marital status. Depressive symptoms, social behaviors, and physical activities were examined as time-varying predictors of mortality over a 30-year period using multiple imputation for missing data and Cox proportional hazards regression, controlling for demographic factors and health risk factors.ResultsBy the end of the study, 137 individuals from the depressed sample and 99 individuals from the comparison sample had died. Although the mortality rate is higher in the depressed sample, after controlling for demographic, health risk factors, social behaviors, and physical activity, there was no significant difference in mortality between the depressed and control samples. Among participants in the depressed sample, reduced participation in social activities was significantly associated with a higher risk of mortality.LimitationsFrequency and intensity of activities were not assessed and all data except for mortality were self-report.ConclusionsPromoting social engagement through activities may hold promise for delaying mortality among individuals who are depressed. Potential methods to promote social engagement and factors such as positive emotions that should be considered in future studies are discussed.
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