Altered Regional Homogeneity in Patients With Corneal Ulcer: A Resting-State Functional MRI Study
Altered Regional Homogeneity in Patients With Corneal Ulcer: A Resting-State Functional MRI Study
复制标题
角膜溃疡患者区域均匀性的改变：静息态功能 MRI 研究
DOI：
10.3389/fnins.2019.00743
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发表时间：
2019-07
影响因子：
4.3
通讯作者：
Yi Shao
中科院分区：
文献类型：
--
作者：
Man-Wei Xu;Hui-Min Liu;Gang Tan;Ting Su;Chu-Qi Xiang;Wei Wu;Biao Li;Qi Lin;Xiao-Wei Xu;You-Lan Min;Wen-feng Liu;Gui-Ping Gao;Yi Shao
目的探讨角膜溃疡（corneal ulcer，CU）患者潜在区域同质性（potential regional homogeneity，ReHo）脑电活动变化及其与临床症状的关系。材料与方法40例CU患者（男26例，女14例）和40例年龄、性别、体重相近的健康对照者（男26例，女14例）分别行静息态功能MRI扫描。应用ReHo方法评价同步神经活动变化。受试者工作特征曲线（ROC曲线）显示了较高的重测稳定性和较高的敏感性和特异性。我们利用相关性分析来计算CU患者不同脑区的平均ReHo信号值与临床症状之间的关系。结果与HC组比较，CU组右侧小脑后叶、左侧小脑后叶、左侧颞下回、右侧舌回、左侧额中回、左侧角回、左侧扣带回、右侧角回、双侧额上级回的ReHo值明显增高，右侧扣带回前、左侧中央前回的ReHo值明显降低。ROC曲线分析显示，除右侧小脑后叶外，各脑区AUC的准确性均较好。然而，没有明确的证据表明大脑区域的平均ReHo值与临床症状之间存在显著相关性。结论角膜溃疡引起不同脑区的功能性适应障碍，包括相对增高和降低。这一发现可能有助于我们进一步探索CU的潜在病理机制。
Objective To investigate the potential regional homogeneity (ReHo) brain activity changes in patients with corneal ulcer (CU) and their possible relationship with clinical symptoms. Materials and Methods Forty patients with CU (26 men and 14 women), and 40 healthy controls (HCs) (26 men and 14 women) closely matched in age, sex, and weight underwent resting-state functional MRI scans, respectively. The ReHo method was applied to evaluate synchronous neural activity changes. Receiver operating characteristic curve (ROC curve) was used to show high test-retest stability and high degree of sensitivity and specificity. We utilized the correlation analysis to calculate the relationship between the average ReHo signal values in different brain areas and the clinical symptoms in CU patients. Results Compared with the HCs, CU patients had significantly increased ReHo values in right cerebellum posterior lobe, left cerebellum posterior lobe, left inferior temporal gyrus, right lingual gyrus, left middle frontal gyrus, left angular gyrus, left cingulate gyrus, right angular gyrus and bilateral superior frontal gyrus, and decreased ReHo values in right anterior cingulate and left precentral gyrus. ROC curve analysis of each brain regions showed the accuracy of AUC was perfect except the right cerebellum posterior lobe. Nevertheless, there was no clear evidence of prominent relevance between the average ReHo values in brain areas and the clinical symptoms. Conclusion Corneal ulcer caused dysfunctional adaption in different brain areas, which including relatively increased values and decreased values. This finding may help us take a further step in exploring the underlying pathologic mechanisms of CU.
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