Altered Regional Cerebral Blood Flow of Right Cerebellum Posterior Lobe in Asthmatic Patients With or Without Depressive Symptoms.
Altered Regional Cerebral Blood Flow of Right Cerebellum Posterior Lobe in Asthmatic Patients With or Without Depressive Symptoms.
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有或无抑郁症状的哮喘患者右小脑后叶局部脑血流的改变
DOI：
10.3389/fpsyt.2018.00225
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发表时间：
2018
影响因子：
4.7
通讯作者：
Yuan Y
中科院分区：
文献类型：
--
作者：
Zhang Y;Yang Y;Wang Z;Bian R;Jiang W;Yin Y;Yue Y;Hou Z;Yuan Y
背景：哮喘是一种与抑郁症相关的慢性疾病。但是哮喘中抑郁症的基础仍然未知。为了了解哮喘患者抑郁的神经机制，我们利用脑血流量（CBF）来探讨抑郁症哮喘（DA）患者与非抑郁症哮喘（NDA）患者的差异。方法：18例DA患者、24例NDA患者和57例健康对照（HC）分别接受脉冲动脉自旋标记（pASL）扫描测量CBF、静息状态功能磁共振成像（rs-fMRI）扫描、抑郁严重程度评估和哮喘控制评估。结果：与NDA相比，DA患者右侧小脑后叶区域CBF （rCBF）增加。与HC相比，DA和NDA患者右小脑后叶rCBF均明显减少。结论：我们使用pASL首次发现哮喘患者右小脑后叶rCBF改变的证据，这可能与哮喘的神经病理学有关。临床试验注册：哮喘患者的治疗机制研究：基于群体认知行为治疗（注册号：ChiCTR-COC-15007442） （http://www.chictr.org.cn/usercenter.aspx）的结果。
Background: Asthma is a chronic disease appeared to be associated with depression. But the underpinnings of depression in asthma remain unknown. In order to understand the neural mechanisms of depression in asthma, we used cerebral blood flow (CBF) to probe the difference between depressed asthmatic (DA) and non-depressed asthmatic (NDA) patients. Methods: Eighteen DA patients, 24 NDA patients and 57 healthy controls (HC) received pulsed arterial spin labeling (pASL) scan for measuring CBF, resting-state functional magnetic resonance imaging (rs-fMRI) scan, severity of depression and asthma control assessment, respectively. Results: Compared to NDA, DA patients showed increased regional CBF (rCBF) in the right cerebellum posterior lobe. Compared to HC, DA, and NDA patients all showed significantly decreased rCBF in the right cerebellum posterior lobe. Conclusions: We showed the first evidence of altered rCBF in the right cerebellum posterior lobe in asthma using pASL, which appeared to be involved in the neuropathology in asthma. Clinical Trial Registration: An investigation of therapeutic mechanism in asthmatic patients: based on the results of Group Cognitive Behavioral Therapy (Registration number: ChiCTR-COC-15007442) (http://www.chictr.org.cn/usercenter.aspx).
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影响因子：
3.7
作者：
Rosenkranz MA;Busse WW;Sheridan JF;Crisafi GM;Davidson RJ
通讯作者：
Davidson RJ
影响因子：
3.7
作者：
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
通讯作者：
Zang YF
早发型和晚发型抑郁症缓解患者的脑血流变化
影响因子：
--
作者：
Liao W;Wang Z;Zhang X;Shu H;Wang Z;Liu D;Zhang Z
通讯作者：
Zhang Z
影响因子：
6.3
作者：
Ray M;Sano M;Wisnivesky JP;Wolf MS;Federman AD
通讯作者：
Federman AD
DOI：
10.1073/pnas.0504365102
发表时间：
2005-09-13
影响因子：
11.1
作者：
Rosenkranz, MA;Busse, WW;Davidson, RJ
通讯作者：
Davidson, RJ