Aging alters across-hemisphere cortical dynamics during binaural temporal processing.
Aging alters across-hemisphere cortical dynamics during binaural temporal processing.
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DOI：
10.3389/fnins.2022.1060172
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发表时间：
2022
影响因子：
4.3
通讯作者：
Eddins, David A.
中科院分区：
文献类型：
--
作者：
Eddins, Ann Clock;Ozmeral, Erol J.;Eddins, David A.
关键词：
声音到达双耳的时间和强度的差异提供了基本的双耳线索，帮助我们定位和隔离环境中的声音。这些线索的神经编码通常在皮层中不对称地表示，在感知空间位置的对侧半球中具有更强的激活。虽然已知年龄的增长会降低双耳线索的感知，但对这些线索的神经表征如何受到年龄的影响知之甚少。在这里，我们使用脑电图（EEG）调查年龄相关的变化，在半球分布的耳间时间差（ITD）编码的基础上皮层听觉诱发电位（CAEPs）和派生的双耳交互分量（BIC）措施在10个年轻人和10个老年人听力正常的成年人。CAEP和BIC的传感器级分析显示，与年龄相关的差异，在全球领域的权力，老年人的听众有显着较大的反应比年轻的双耳指标。源级分析表明，半球的差异，听觉皮层活动的左，右偏侧刺激年轻人，对侧激活模型处理ITDs一致。然而，老年人在ITD中表现出减少的半球不对称性，尽管总体上比年轻人有更大的反应。此外，当在ITD条件下取平均值以评估皮质不对称性随时间的变化时，与源波形中的峰值分量（P1，N1，P2）对应的偏侧性存在显著偏移，这也受年龄的影响。这些新的结果表明，在双耳时间处理，随着年龄的增长而改变的跨半球皮层动力学。
Differences in the timing and intensity of sounds arriving at the two ears provide fundamental binaural cues that help us localize and segregate sounds in the environment. Neural encoding of these cues is commonly represented asymmetrically in the cortex with stronger activation in the hemisphere contralateral to the perceived spatial location. Although advancing age is known to degrade the perception of binaural cues, less is known about how the neural representation of such cues is impacted by age. Here, we use electroencephalography (EEG) to investigate age-related changes in the hemispheric distribution of interaural time difference (ITD) encoding based on cortical auditory evoked potentials (CAEPs) and derived binaural interaction component (BIC) measures in ten younger and ten older normal-hearing adults. Sensor-level analyses of the CAEP and BIC showed age-related differences in global field power, where older listeners had significantly larger responses than younger for both binaural metrics. Source-level analyses showed hemispheric differences in auditory cortex activity for left and right lateralized stimuli in younger adults, consistent with a contralateral activation model for processing ITDs. Older adults, however, showed reduced hemispheric asymmetry across ITDs, despite having overall larger responses than younger adults. Further, when averaged across ITD condition to evaluate changes in cortical asymmetry over time, there was a significant shift in laterality corresponding to the peak components (P1, N1, P2) in the source waveform that also was affected by age. These novel results demonstrate across-hemisphere cortical dynamics during binaural temporal processing that are altered with advancing age.
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