Frontal brain asymmetry in depression with comorbid anxiety: a neuropsychological investigation.
Frontal brain asymmetry in depression with comorbid anxiety: a neuropsychological investigation.
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DOI：
10.1037/a0027587
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发表时间：
2012-08
影响因子：
4.6
通讯作者：
Shankman, Stewart A.
中科院分区：
文献类型：
--
作者：
Nelson, Brady D.;Sarapas, Casey;Robison-Andrew, E. Jenna;Altman, Sarah E.;Campbell, Miranda L.;Shankman, Stewart A.
接近-退缩模型假定抑郁和焦虑与额叶脑活动的相对右侧不对称有关。大多数研究都使用脑皮层活动的测量方法（如脑电图）来测试这个模型。然而，区别地使用左与右额叶皮质区域的神经心理学任务也可以用于测试来自模型的假设。在两个独立的样本（研究1和2），本研究调查的表现，目前抑郁症的个人或没有共病焦虑症和健康的控制神经心理任务，主要是左（语言流畅性）或右（设计流畅性）额叶脑区。在这两个样本中，结果表明，共病参与者比抑郁症和控制参与者的设计流畅性更差，而所有组的语言流畅性表现相当。此外，共病参与者在这两项任务上表现出“不对称”的表现（即，较差的设计[右额叶]相对于语言[左额叶]流畅性），而抑郁症和对照组的参与者表现出大致对称的表现轮廓。这两个样本的结果表明，在焦虑抑郁个体中，神经认知表现的异常额叶不对称主要是由右额叶功能障碍引起的，并强调了在检查抑郁症的额叶功能时考虑共病焦虑的重要性。
The approach-withdrawal model posits that depression and anxiety are associated with a relative right asymmetry in frontal brain activity. Most studies have tested this model using measures of cortical brain activity such as electroencephalography. However, neuropsychological tasks that differentially employ left vs. right frontal cortical regions can also be used to test hypotheses from the model. In two independent samples (Study 1 and 2), the present study investigated the performance of currently depressed individuals with or without a comorbid anxiety disorder and healthy controls on neuropsychological tasks tapping primarily left (verbal fluency) or right (design fluency) frontal brain regions. Across both samples, results indicated that comorbid participants performed more poorly than depressed only and control participants on design fluency, while all groups showed equivalent performance on verbal fluency. Moreover, comorbid participants showed “asymmetrical” performance on these two tasks (i.e., poorer design [right frontal] relative to verbal [left frontal] fluency), while depressed only and control participants showed approximately symmetrical profiles of performance. Results from these two samples suggest an abnormal frontal asymmetry in neurocognitive performance driven primarily by right frontal dysfunction among anxious-depressed individuals and highlight the importance of considering comorbid anxiety when examining frontal brain functioning in depression.
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影响因子：
2.6
作者：
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通讯作者：
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作者：
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