Long-term effects of prenatal cigarette smoke exposure on behavior dysregulation among 14-year-old offspring of teenage mothers.
Long-term effects of prenatal cigarette smoke exposure on behavior dysregulation among 14-year-old offspring of teenage mothers.
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DOI：
10.1007/s10995-011-0766-0
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发表时间：
2012-04
影响因子：
2.3
通讯作者：
Larkby C
中科院分区：
文献类型：
--
作者：
Cornelius MD;Goldschmidt L;De Genna NM;Larkby C
在这项前瞻性研究中，我们研究了产前吸烟暴露（PCSE）对青少年母亲后代行为失调（BD）的长期影响。青少年母亲（平均年龄= 16;范围= 12-18; 70%的非洲裔美国人）进行了采访，他们在怀孕期间的烟草使用。后代随访至14岁（n = 318）。BD结果的指标包括攻击性、违反规则、外化、社会问题、注意力、注意力分散和活动。多个措施和多个线人被用于每个结构。进行回归分析，以测试PCSE是否预测BD的结果，调整人口统计学和母亲的心理特征，以及产前暴露于其他物质。PCSE的独立影响被发现，暴露的后代有更多的攻击性，社会和外化的问题，母亲的报告和青少年的自我报告措施。他们更活跃，有更多的注意力问题，更难分心和任务导向。大多数PCSE效应来自妊娠早期暴露和每天暴露于10支香烟。这些结果与先前在该队列中的发现一致，当时后代为6岁和10岁，表明产前吸烟暴露的影响可以在早期发现并持续到青春期。
In this prospective study, we examined the long-term effects of prenatal cigarette smoke exposure (PCSE) on behavioral dysregulation (BD) in the offspring of adolescent mothers. The adolescent mothers (mean age = 16; range = 12–18; 70% African American) were interviewed about their tobacco use during pregnancy. Offspring were followed to age 14 years (n = 318). Indices of BD outcomes included aggression, rule breaking, externalizing, social problems, attention, distractibility and activity. Multiple measures and multiple informants were used for each construct. Regression analyses were conducted to test if PCSE predicted the BD outcomes, adjusting for demographic and maternal psychological characteristics, and for prenatal exposure to other substances. Independent effects of PCSE were found. Exposed offspring had more aggressive, social, and externalizing problems on both the maternal report and the adolescent self-report measures. They were more active, had more attention problems and greater difficulty with distraction and task orientation. Most PCSE effects were found from first trimester exposure and from exposure to as few as 10 cigarettes per day. These results are consistent with previous findings in this cohort when offspring were 6 and 10 years old, demonstrating that the effects of prenatal cigarette smoke exposure can be identified early and persist into adolescence.
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影响因子：
4.7
作者：
Cornelius, Marie D.;Goldschmidt, Lidush;Day, Nancy L.
通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
TAYLOR, P
影响因子：
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作者：
Cornelius, MD;Goldschmidt, L;Larkby, C
通讯作者：
Larkby, C
影响因子：
4.8
作者：
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通讯作者：
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