Psychiatric comorbidities, sexual health and neurodevelopmental outcomes of offspring in men with epilepsy.
Psychiatric comorbidities, sexual health and neurodevelopmental outcomes of offspring in men with epilepsy.
复制标题
DOI：
10.1016/j.yebeh.2020.107562
复制
发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Fields MC
中科院分区：
文献类型：
--
作者：
Casale M;Lemus HN;Young JJ;Marcuse LV;Yoo JY;Faktorovich S;Mueller B;Fields MC
在文献中，关于男性癫痫患者使用抗癫痫药物（ASM）的数据很少。当前的研究调查了与对照组相比，患有ASM的癫痫男性的后代的受孕时间以及妊娠和神经发育结果。此外，还分析了精神共病的患病率，以及癫痫和非癫痫男性的性行为指标。在一家医院，共有450例男性癫痫患者和非癫痫患者提供问卷调查，以确定人口统计学特征，癫痫病史，在怀孕时的ASM类型，合并症和性健康。记录了受孕时间、生育方法和患有和不患有癫痫的雄性所生后代的出生和发育史。连续变量采用Student t检验，分类变量采用Fisher精确检验，对调查数据进行评价。计算比值比（OR）以确定测量数据之间的关联。在年龄匹配后，我们分析了110名癫痫男性和110名非癫痫男性。与对照组相比，癫痫组的精神共病率较高，如重度抑郁症、广泛性焦虑症、双相情感障碍和自杀意念（N = 110; OR 3.39; 95%IC：1.87-6.13，p < 0.001）。与无癫痫的男性相比，癫痫男性勃起评分低的频率也更高（N = 70例癫痫，N = 76例无癫痫; OR 3.67; 95% IC：1.44-9.39，p = 0.005）。在110名诊断为癫痫的男性中，17名在使用ASM时怀孕（共38名儿童）。与对照组的2.63%相比，ASM组父亲所生的儿童共有18.42%经历了发育迟缓，但该结果无统计学意义（p = 0.056）。此外，我们没有发现与对照组相比，ASM组男性的后代出生体重或胎龄有显著差异（p > 0.05）。目前的研究表明，与无癫痫的男性相比，患有癫痫的男性精神共病的发病率增加，性行为改变，特别是勃起功能障碍。有没有统计学上的显着差异，这些男性癫痫患者在怀孕和控制时的ASM之间的发育障碍和出生特征的比率。
There is a paucity of data in the literature specific to men with epilepsy on anti-seizure medication (ASM). The current study investigated the time to conception as well as the gestational and the neurodevelopmental outcomes of offspring of men with epilepsy on ASM compared to controls. Additionally, the prevalence of psychiatric comorbidities, and measures of sexual performance in males with and without epilepsy were analyzed. A total of 450 male patients with and without epilepsy at one hospital were provided questionnaires to determine demographic characteristics, epilepsy history, type of ASM at the time of conception, comorbidities and sexual health. Time to conception, fertility methods and offspring birth and developmental history born to males with and without epilepsy was recorded. Survey data was evaluated using Student’s t-test for continuous variables and Fisher’s exact test for categorical variables. Odds ratio (OR) were calculated to determine associations between the measured data. After matching for age, we analyzed a total of 110 males with epilepsy and 110 without epilepsy. In the epilepsy group there was a higher rate of psychiatric comorbidities such as major depressive disorder, general anxiety disorder, bipolar disorder, and suicidal ideation when compared to the control group (N = 110; OR 3.39; 95% IC: 1.87–6.13, p < 0.001). Males with epilepsy also had a higher frequency of low erection scores when compared to males without epilepsy (N = 70 with epilepsy, N = 76 without epilepsy; OR 3.67; 95% IC: 1.44–9.39, p = 0.005). Of the 110 men with a diagnosis of epilepsy, 17 conceived children while using ASMs (38 total children). A total of 18.42% of children born to fathers on ASMs experienced developmental delays compared to 2.63% of controls, however this result was not statistically significant (p = 0.056). In addition, we did not find that offspring had significantly different birth weights or gestational ages in men on ASM compared to controls (p > 0.05). The present study suggests that men with epilepsy have an increased incidence of psychiatric comorbidities, and altered sexual performance, specifically erectile dysfunction, when compared with men without epilepsy. There was no statistically significant difference in the rates of developmental disorders and birth characteristics among those men with epilepsy on ASM at the time of conception and controls.
登录
查看更多内容
影响因子：
7.3
作者：
Hou, Cai-Lan;Zang, Yu;Xiang, Yu-Tao
通讯作者：
Xiang, Yu-Tao
影响因子：
3.5
作者：
Ocek, L.;Tarhan, H.;Zorlu, Y.
通讯作者：
Zorlu, Y.
影响因子：
5.6
作者：
DANSKY, LV;ANDERMANN, E;ANDERMANN, F
通讯作者：
ANDERMANN, F
影响因子：
9.9
作者：
Kim, Anna M.;Rossi, Kyle C.;Dhamoon, Mandip S.
通讯作者：
Dhamoon, Mandip S.
影响因子：
6.3
作者：
Goisis A;Remes H;Barclay K;Martikainen P;Myrskylä M
通讯作者：
Myrskylä M