Paternal age and the risk of low birth weight and preterm delivery: a Finnish register-based study.
Paternal age and the risk of low birth weight and preterm delivery: a Finnish register-based study.
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DOI：
10.1136/jech-2017-210170
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发表时间：
2018-12
影响因子：
6.3
通讯作者：
Myrskylä M
中科院分区：
文献类型：
--
作者：
Goisis A;Remes H;Barclay K;Martikainen P;Myrskylä M
根据现有的研究，没有确凿的证据表明父亲的年龄是否以及为什么对出生结果有影响。我们使用芬兰人口登记册对1987-2000年出生的106652名儿童进行了调查。我们首先记录了父亲年龄与低出生体重（LBW; <2500 g）和早产（<37周妊娠）风险之间的未校正关联。其次，我们调查是否未调整的关联是衰减调整儿童，母亲和父母的社会经济特征。第三，通过采用家庭内的设计，包括比较不同年龄的同一父亲所生的孩子，我们还调整了兄弟姐妹之间未观察到的父母特征。未校正的结果显示，与30-34岁的父亲相比，40岁以上的父亲所生的孩子，LBW风险增加0.96%（95% CI 0.5%至1.3%），年轻父亲（<25岁）的风险增加1%（95% CI 0.6%至1.3%）。在父亲年龄较小时增加的风险在调整孩子的特征后减半，在调整孩子/父母的特征后完全减弱。父亲年龄40岁以上的风险增加在校正母亲特征后部分减弱（β=0.62%; 95% CI 0.13%至1.1%）。对兄弟姐妹共有的未观察到的父母特征进行调整，进一步削弱了40+系数（β=0.4%; 95%CI-0.5%至-1.2%）。早产的结果相似。研究结果强调了将父亲年龄视为不良出生结果的潜在风险因素以及扩大对其作用及其与出生结果联系的机制的研究的重要性。
Based on existing studies, there is no conclusive evidence as to whether and why paternal age matters for birth outcomes. We used Finnish population registers on 106 652 children born 1987–2000. We first document the unadjusted association between paternal age and the risk of low birth weight (LBW; <2500 g) and preterm birth (<37 weeks’ gestation). Second, we investigate whether the unadjusted association is attenuated on adjustment for child’s, maternal and parental socioeconomic characteristics. Third, by adopting a within-family design which involves comparing children born to the same father at different ages, we additionally adjust for unobserved parental characteristics shared between siblings. The unadjusted results show that being born to a father aged 40+, as opposed to a father aged 30–34, is associated with an increased risk of LBW of 0.96% (95% CI 0.5% to 1.3%) and to a younger father (<25) with a 1% (95% CI 0.6% to 1.3%) increased risk. The increased risk at younger paternal ages is halved on adjustment for the child’s characteristics and fully attenuated on adjustment for child/parental characteristics. The increased risk at paternal ages 40+ is partially attenuated on adjustment for maternal characteristics (β=0.62%; 95% CI 0.13% to 1.1%). Adjustment for unobserved parental characteristics shared by siblings further attenuates the 40+ coefficient (β=0.4%; 95% CI −0.5% to −1.2%). Results for preterm delivery are similar. The results underscore the importance of considering paternal age as a potential risk factor for adverse birth outcomes and of expanding research on its role and the mechanisms linking it to birth outcomes.
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影响因子：
5.4
作者：
Astolfi, P;De Pasquale, A;Zonta, LA
通讯作者：
Zonta, LA
DOI：
10.1016/0165-1218(95)90043-8
发表时间：
1995-08-01
期刊：
MUTATION RESEARCH-GENETIC TOXICOLOGY
影响因子：
--
作者：
OLSHAN, AF;ANANTH, CV;SAVITZ, DA
通讯作者：
SAVITZ, DA
影响因子：
12.7
作者：
Reichman, NE;Teitler, JO
通讯作者：
Teitler, JO
影响因子：
5.4
作者：
Zhu, JL;Madsen, KM;Olsen, J
通讯作者：
Olsen, J
影响因子：
5.4
作者：
Basso, Olga;Wilcox, Allen J.
通讯作者：
Wilcox, Allen J.