Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia.
Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia.
复制标题
DOI：
10.1038/sj.bjc.6604785
复制
发表时间：
2008-12-16
影响因子：
8.8
通讯作者：
van Helvoort A
中科院分区：
文献类型：
--
作者：
Faber J;Vos P;Kegler D;van Norren K;Argilés JM;Laviano A;Garssen J;van Helvoort A
大多数晚期癌症患者通过受多种因素影响的免疫能力受损而被识别，包括肿瘤的类型和阶段以及恶病质的存在。最近，一种含有鱼油、特定低聚糖混合物、高蛋白含量和亮氨酸的特殊营养组合被开发出来，旨在支持癌症患者的免疫系统，以减少（感染性）并发症的频率和严重程度。在最近改良的动物模型中，接种C26肿瘤细胞可诱导小鼠恶病质。在恶病质前状态下，在荷瘤小鼠的饮食中添加个体营养成分后，未观察到接触性超敏反应（一种有效的体内方法，用于测量th1介导的免疫功能）的影响。然而，完全混合导致Th1免疫力显著提高。此外，在病毒质状态下，完全混合降低了血浆中促炎细胞因子的水平，并有益地影响了体外免疫功能。因此，需要这些营养成分的组合来获得协同效应，从而减少炎症状态，提高免疫能力。由此可以得出结论，特定的营养组合具有潜在的免疫支持营养干预，以降低癌症患者（感染性）并发症的风险。
The majority of patients with advanced cancer are recognised by impaired immune competence influenced by several factors, including the type and stage of the tumour and the presence of cachexia. Recently, a specific nutritional combination containing fish oil, specific oligosaccharide mixture, high protein content and leucine has been developed aimed to support the immune system of cancer patients in order to reduce the frequency and severity of (infectious) complications. In a recently modified animal model cachexia is induced by inoculation of C26 tumour cells in mice. In a pre-cachectic state, no effect was observed on contact hypersensitivity, a validated in vivo method to measure Th1-mediated immune function, after adding the individual nutritional ingredients to the diet of tumour-bearing mice. However, the complete mixture resulted in significantly improved Th1 immunity. Moreover, in a cachectic state, the complete mixture reduced plasma levels of pro-inflammatory cytokines and beneficially affected ex vivo immune function. Accordingly, the combination of the nutritional ingredients is required to obtain a synergistic effect, leading to a reduced inflammatory state and improved immune competence. From this, it can be concluded that the specific nutritional combination has potential as immune-supporting nutritional intervention to reduce the risk of (infectious) complications in cancer patients.
登录
查看更多内容
影响因子：
7.1
作者：
Calder, Philip C.
通讯作者：
Calder, Philip C.
DOI：
10.1097/01.mco.0000078983.18774.cc
发表时间：
2003-07-01
影响因子：
3.1
作者：
Argilés, JM;Busquets, S;López-Soriano, FJ
通讯作者：
López-Soriano, FJ
影响因子：
6.2
作者：
ANDERSON, TC;JONES, SE;STANLEY, P
通讯作者：
STANLEY, P
影响因子：
9
作者：
HAFFEJEE, AA;ANGORN, IB
通讯作者：
ANGORN, IB
影响因子：
4.4
作者：
Pizato, N;Bonatto, S;Fernandes, LC
通讯作者：
Fernandes, LC