Brain vulnerability to chemotherapy toxicities.
Brain vulnerability to chemotherapy toxicities.
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DOI：
10.1002/pon.3196
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发表时间：
2012-11
期刊：
影响因子：
3.6
通讯作者：
Ahles, Tim A.
中科院分区：
文献类型：
--
作者：
Ahles, Tim A.
Chemotherapy-induced cognitive changes have been an increasing concern among cancer survivors. Using adjuvant treatment for breast cancer as the prototype, this manuscript reviews research from neuropsychological, imaging, genetic, and animal model studies that have examined the clinical presentation and potential mechanisms for cognitive changes associated with exposure to chemotherapy. An impressive body of research supports the hypothesis that a subgroup of patients is vulnerable to post-treatment cognitive changes, although not exclusively related to chemotherapy. Further, imaging and animal model studies are providing accumulating evidence for putative mechanisms for chemotherapy-induced cognitive change. Models of aging are also reviewed in support of the proposal that cognitive changes associated with cancer and cancer treatments can be viewed in the context of factors that affect the trajectory of normal aging.
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