Impact of prolapse meshes on the metabolism of vaginal extracellular matrix in rhesus macaque.
Impact of prolapse meshes on the metabolism of vaginal extracellular matrix in rhesus macaque.
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脱垂网络对恒河猕猴阴道细胞外基质代谢的影响。
DOI：
10.1016/j.ajog.2014.08.008
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发表时间：
2015-02
影响因子：
9.8
通讯作者：
Moalli, Pamela A.
中科院分区：
文献类型：
--
作者：
Liang, Rui;Zong, Wenjun;Palcsey, Stacy;Abramowitch, Steven;Moalli, Pamela A.
使用非人灵长类动物模型分析聚丙烯补片植入对阴道胶原蛋白和弹性蛋白代谢的影响，以进一步描述补片诱导并发症的机制。49只中年经产恒河猴经骶骨阴道固定术植入3枚人工合成补片。植入Gynemesh PS（n=12）和两种重量较轻、孔隙率较高、刚度较低的补片- UltraPro（n = 19）和Restorelle（n=8），其中UltraPro的蓝色定向线垂直（低刚度方向，n=11）和平行（高刚度方向，n=8）阴道纵轴植入。假手术动物用作对照（n=10）。术后12周，切除网状组织复合体并进行分析。相对于Sham，Gynemesh PS对胶原蛋白和弹性蛋白的代谢均产生负面影响，有利于分解代谢反应，而UltraPro仅诱导弹性蛋白降解增加。Restorelle的影响最小。与假手术组相比，Gynemesh PS组阴道中胶原和弹性蛋白降解增加，同时活性MMP-1、-8、-13和总MMP-2、-9增加（均P<0.05）。植入UltraPro的阴道中弹性蛋白（原弹性蛋白和成熟弹性蛋白）的降解增加，同时MMP-2和-9增加（均P<0.05）。Gynemesh PS组和UltraPro垂直组胶原亚型III/I比值均升高（P<0.05）。在植入较重、孔隙较少且较硬的补片Gynemesh PS后，阴道胶原蛋白和弹性蛋白的降解超过合成，最可能是由于MMP活性增加，导致组织结构受损。
The impact of polypropylene mesh implantation on vaginal collagen and elastin metabolism was analyzed using a nonhuman primate model to further delineate the mechanism of mesh induced complications. 49 middle aged parous rhesus macaques underwent surgical implantation of 3 synthetic meshes via sacrocolpopexy. Gynemesh PS (n=12) and two lower weight, higher porosity, lower stiffness meshes - UltraPro (n = 19) and Restorelle (n=8) were implanted, in which UltraPro was implanted with its blue orientation lines perpendicular (low stiffness direction, n=11) and parallel (high stiffness direction, n=8) to the longitudinal axis of vagina. Sham operated animals were used as controls (n=10). Twelve weeks after surgery, the meshtissue complex was excised and analyzed. Relative to Sham, Gynemesh PS had a negative impact on the metabolism of both collagen and elastin favoring catabolic reactions while UltraPro only induced an increase in elastin degradation. Restorelle had the least impact. As compared to Sham, the degradation of collagen and elastin in the vagina implanted with Gynemesh PS was increased with a simultaneous increase in active MMP-1, -8, -13 and total MMP-2, -9 (all P<0.05). The degradation of elastin (tropoelastin and mature elastin) was increased in the UltraPro implanted vagina with a concomitant increase of MMP-2, and -9 (all P<0.05). Collagen subtype ratio III/I was increased in both Gynemesh PS and UltraPro perpendicular groups (P<0.05). Following implantation with the heavier, less porous and stiffer mesh, Gynemesh PS, the degradation of vaginal collagen and elastin exceeded synthesis, most likely as a result of increased activity of MMPs, resulting in a structurally compromised tissue.
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影响因子：
2.8
作者：
Eriksen, HA;Pajala, A;Risteli, J
通讯作者：
Risteli, J
DOI：
10.1016/s0006-291x(76)80180-5
发表时间：
1976-01-01
影响因子：
3.1
作者：
SYKES, B;PUDDLE, B;SMITH, R
通讯作者：
SMITH, R
影响因子：
6
作者：
Drewes, Peter G.;Yanagisawa, Hiromi;Word, R. Ann
通讯作者：
Word, R. Ann
影响因子：
3.8
作者：
Niyibizi, C;Kavalkovich, K;Woo, SLY
通讯作者：
Woo, SLY
DOI：
10.1002/jbm.10119
发表时间：
2002-04-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
Klinge, U;Junge, K;Klosterhalfen, B
通讯作者：
Klosterhalfen, B