Anticipatory pleasure predicts motivation for reward in major depression.
Anticipatory pleasure predicts motivation for reward in major depression.
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预期愉悦预测重度抑郁症的奖励动机。
DOI：
10.1037/a0024945
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发表时间：
2012-02
影响因子：
4.6
通讯作者：
Gotlib IH
中科院分区：
文献类型：
--
作者：
Sherdell L;Waugh CE;Gotlib IH
快感缺乏，即对享乐刺激或体验缺乏兴趣或快乐，是抑郁症的主要症状。这种享乐加工的缺陷被认为会影响抑郁的人参与潜在回报体验的动机。越来越多的证据表明，享乐加工不是一个单一的结构，而是由预期阶段和完成阶段组成。我们研究了享乐处理的这些组成部分如何影响被诊断为严重抑郁症的参与者和从未紊乱的对照组获得奖励的动机。38名目前抑郁的受试者和30名从未失调症的对照组参与者对他们对幽默和非幽默动画片的喜好进行了评级，然后在观看这两组卡通片之间做出了一系列选择。每个选择都与参与者在观看所选卡通之前必须付出的特定努力量相关联。尽管抑郁和控制组参与者在对奖励的完成性喜好上没有差异，但奖赏喜好水平只在控制组参与者中预测了为奖励付出努力的动机；在抑郁组参与者中，喜好和动机是分离的。在抑郁的人群中，预期性快感缺乏的水平预示着为奖励而努力的动机。这些发现支持快感缺失不是一个单一结构的说法，并表明，对于抑郁的人来说，奖励动机的不足主要是由较低的预期快感驱动的，而不是由减少的消费喜好驱动的。
Anhedonia, the lack of interest or pleasure in response to hedonic stimuli or experiences, is a cardinal symptom of depression. This deficit in hedonic processing has been posited to influence depressed individuals’ motivation to engage in potentially rewarding experiences. Accumulating evidence indicates that hedonic processing is not a unitary construct but rather consists of an anticipatory and a consummatory phase. We examined how these components of hedonic processing influence motivation to obtain reward in participants diagnosed with major depression and in never-disordered controls. Thirty-eight currently depressed and 30 never-disordered control participants rated their liking of humorous and nonhumorous cartoons and then made a series of choices between viewing a cartoon from either group. Each choice was associated with a specified amount of effort participants would have to exert before viewing the chosen cartoon. Although depressed and control participants did not differ in their consummatory liking of the rewards, levels of reward liking predicted motivation to expend effort for the rewards only in the control participants; in the depressed participants, liking and motivation were dissociated. In the depressed group, levels of anticipatory anhedonia predicted motivation to exert effort for the rewards. These findings support the formulation that anhedonia is not a unitary construct and suggest that, for depressed individuals, deficits in motivation for reward are driven primarily by low anticipatory pleasure and not by decreased consummatory liking.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
3.3
作者：
Gard, David E.;Gard, Marja Germans;John, Oliver P.
通讯作者：
John, Oliver P.
影响因子：
2.7
作者：
Correa, M;Carlson, BB;Salamone, JD
通讯作者：
Salamone, JD
影响因子：
2.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
3.7
作者：
Dillon, Daniel G.;Holmes, Avram J.;Pizzagalli, Diego A.
通讯作者：
Pizzagalli, Diego A.