Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges.
Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges.
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DOI：
10.1007/s00213-011-2458-2
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发表时间：
2012-01
影响因子：
3.4
通讯作者：
Semenova, Svetlana
中科院分区：
文献类型：
--
作者：
Semenova, Svetlana
关键词：
酒精滥用在青少年中很普遍，但酗酒的长期行为后果尚不清楚。本研究旨在探讨青少年间歇性酒精暴露（AIE）对注意力和冲动性的长期影响。将青春期雄性大鼠暴露于5 g/kg的25%v/w乙醇，每8 h一次，持续4天。在成年期，在5-选择系列反应时间任务（5-CSRTT）中测试大鼠，评估注意力、冲动性和认知灵活性。在AIE暴露期间，青春期大鼠对乙醇没有代谢耐受性。在基线条件下的5-CSRTT中，AIE暴露组和对照组大鼠在准确性、遗漏或过早反应方面没有差异，但AIE暴露组大鼠比对照组大鼠倾向于做出更多的超时反应。短时间的刺激挑战减少准确性和增加遗漏和超时反应在AIE暴露和对照组大鼠。长试验间隔激发增加了所有大鼠的过早反应。乙醇的挑战减少了正确的反应，并增加遗漏的控制，但不是在AIE暴露，大鼠。对照组，但不是AIE暴露，大鼠表现出减少过早和超时反应后，乙醇给药。在AIE暴露或对照组大鼠中，反应性乳酸没有受到影响，表明乙醇激发没有镇静作用。结果表明，青春期酒精狂欢暴露具有持久的神经行为后果，持续到成年期，并可在再次暴露于酒精后显示。AIE诱导的对酒精对注意力、冲动性和认知灵活性的破坏性影响的反应减弱可能导致成年期饮酒和其他适应不良行为的增加。
Alcohol abuse is prevalent in adolescent humans, but the long-term behavioral consequences of binge alcohol drinking are unknown. This study investigated the long-term effects of adolescent intermittent ethanol (AIE) exposure on attention and impulsivity. Adolescent male rats were exposed to 5 g/kg of 25% v/w ethanol every 8 h for 4 days. During adulthood rats were tested in the 5-choice serial reaction time task (5-CSRTT) assessing attention, impulsivity and cognitive flexibility. There was no metabolic tolerance to ethanol in adolescent rats during AIE exposure. In the 5-CSRTT under baseline conditions, there were no differences between AIE-exposed and control rats in accuracy, omissions or premature responses, although AIE-exposed rats tended to make more timeout responses than control rats. The short-duration stimulus challenge decreased accuracy and increased omissions and timeout responses in both AIE-exposed and control rats. The long intertrial interval challenge increased premature responses in all rats. An ethanol challenge decreased correct responses, and increased omissions in control, but not in AIE-exposed, rats. Control, but not AIE-exposed, rats exhibited decreased premature and timeout responses after ethanol administration. Response latencies were not affected in AIE-exposed or control rats indicating no sedative effects of ethanol challenge. The results indicate that ethanol binge exposure during adolescence has long-lasting neurobehavioral consequences, which persist into adulthood and can be revealed after re-exposure to ethanol. AIE-induced diminished responses to disruptive effects of ethanol on attention, impulsivity and cognitive flexibility may lead to increased alcohol drinking and other maladaptive behaviors in adulthood.
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影响因子：
4.2
作者：
Bizarro, L;Patel, S;Stolerman, IP
通讯作者：
Stolerman, IP
DOI：
10.1016/j.alcohol.2009.10.017
发表时间：
2010-02
期刊：
Alcohol (Fayetteville, N.Y.)
影响因子：
--
作者：
Morris SA;Kelso ML;Liput DJ;Marshall SA;Nixon K
通讯作者：
Nixon K
影响因子：
3.5
作者：
Morris, Stephanie A.;Eaves, David W.;Smith, Aleksander R.;Nixon, Kimberly
通讯作者：
Nixon, Kimberly
影响因子：
3.4
作者：
Mirza, NR;Stolerman, IP
通讯作者：
Stolerman, IP
影响因子：
3.4
作者：
Evenden, JL;Ryan, CN
通讯作者：
Ryan, CN