Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women.
Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women.
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DOI：
10.1016/j.jdiacomp.2013.11.007
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发表时间：
2014-03
影响因子：
3
通讯作者：
Kahn SE
中科院分区：
文献类型：
--
作者：
Utzschneider KM;Largajolli A;Bertoldo A;Marcovina S;Nelson JE;Yeh MM;Kowdley KV;Kahn SE
我们试图确定NAFLD是否与β细胞功能较差有关，以及是否有任何β细胞功能障碍与铁或炎症的异常标志物有关。这是一项横断面研究，包括15名非糖尿病成人NAFLD和15名非糖尿病年龄和BMI匹配的对照组。胰岛素敏感性通过同位素标记的高胰岛素-正常血糖钳夹测量，β细胞功能通过口服（OGTT）和静脉内葡萄糖耐量试验测量。通过CT扫描评估肝脏和腹部脂肪组成。检测空腹血清铁蛋白、转铁蛋白-铁饱和度、IL-6、TNFα和hsCRP水平。与对照组相比，NAFLD受试者具有较低的肝脏和全身胰岛素敏感性，并且通过口服处置指数测量β细胞功能降低。空腹血清铁蛋白和转铁蛋白铁饱和度在NAFLD中较高，并且与肝脏脂肪呈正相关。血清铁蛋白与口服和静脉试验测定的β细胞功能呈负相关，但与胰岛素敏感性无关。IL-6、TNFα和hsCRP在组间无差异，且与血清铁蛋白、肝脏脂肪或β细胞功能指标无关。这些发现支持铁代谢、肝脏脂肪和糖尿病风险之间的潜在病理生理学联系。
We sought to determine whether NAFLD is associated with poorer β-cell function and if any β-cell dysfunction is associated with abnormal markers of iron or inflammation. This was a cross-sectional study of 15 non-diabetic adults with NAFLD and 15 non-diabetic age and BMI-matched controls. Insulin sensitivity was measured by isotope-labeled hyperinsulinemic-euglycemic clamps and β-cell function by both oral (OGTT) and intravenous glucose tolerance tests. Liver and abdominal fat composition was evaluated by CT scan. Fasting serum levels of ferritin, transferrin-iron saturation, IL-6, TNFα and hsCRP were measured. Compared to controls, subjects with NAFLD had lower hepatic and systemic insulin sensitivity and β-cell function was decreased as measured by the oral disposition index. Fasting serum ferritin and transferrin-iron saturation were higher in NAFLD and were positively associated with liver fat. Serum ferritin was negatively associated with β-cell function measured by both oral and intravenous tests, but was not associated with insulin sensitivity. IL-6, TNFα and hsCRP did not differ between groups and did not correlate with serum ferritin, liver fat or measures of β-cell function. These findings support a potential pathophysiological link between iron metabolism, liver fat and diabetes risk.
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DOI：
10.1016/j.numecd.2010.05.003
发表时间：
2012-02-01
影响因子：
3.9
作者：
Bedogni, G.;Gastaldelli, A.;Sartorio, A.
通讯作者：
Sartorio, A.
影响因子：
7.7
作者：
Fernández-Real, JM;Peñarroja, G;Ricart, W
通讯作者：
Ricart, W
影响因子：
6.7
作者：
LONGO, R;RICCI, C;PALMA, LD
通讯作者：
PALMA, LD
影响因子：
4.9
作者：
Hsiao, TJ;Chen, JC;Wang, JD
通讯作者：
Wang, JD
影响因子：
4.3
作者：
Licata, Anna;Nebbia, Maria Elena;Camma, Calogero
通讯作者：
Camma, Calogero