Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation).
Enhanced sympathetic activity in mice with brown adipose tissue transplantation (transBATation).
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DOI：
10.1016/j.physbeh.2013.11.008
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发表时间：
2014-02-10
影响因子：
2.9
通讯作者：
Shi H
中科院分区：
文献类型：
--
作者：
Zhu Z;Spicer EG;Gavini CK;Goudjo-Ako AJ;Novak CM;Shi H
棕色脂肪组织（BAT）燃烧卡路里产生热量，因此与能量平衡有关。将供体小鼠的肩胛间 BAT (IBAT) 移植到受体小鼠 (transBATation) 中。为了测试 transBATation 是否可以抵消高脂肪饮食 (HFD) 诱导的肥胖，一些假手术小鼠和受体小鼠被喂食 HFD (HFD-sham, HFD-trans)，而其他小鼠则继续吃标准食物 (chow-sham, chow-trans)。与 HFD 假小鼠相比，HFD 转基因小鼠的体重和脂肪较低，能量消耗较多，但热量摄入相似。我们假设，与 HFD 假小鼠相比，HFD 转基因小鼠的交感神经活性升高，从而导致能量消耗和燃料动员增加。研究结果证实了这一点：与 HFD 假小鼠相比，HFD 转基因小鼠在去甲肾上腺素激发试验中能量消耗更大，寒冷暴露后核心温度更高，这表明全身代谢反应增强，交感神经活动增强。此外，transBATation 选择性地增加了对部分（但不是全部）白色脂肪组织库和骨骼肌以及内源性 IBAT、心脏和肝脏的交感神经驱动。总的来说，transBATation 通过增加全身交感神经活动以及对参与能量消耗和燃料动员的一些组织的交感神经驱动的差异激活来抵抗 HFD 诱导的肥胖。
Brown adipose tissue (BAT) burns calories to produce heat, and is thus relevant to energy balance. Interscapular BAT (IBAT) of donor mice was transplanted into recipient mice (transBATation). To test whether transBATation counteracts high-fat diet (HFD)-induced obesity, some sham-operated and recipient mice were fed a HFD (HFD-sham, HFD-trans) while others remained on a standard chow (chow-sham, chow-trans). HFD-trans mice had lower body weight and fat, greater energy expenditure, but similar caloric intake compared with HFD-sham mice. We hypothesized that HFD-trans mice had elevated sympathetic activity compared with HFD-sham mice, contributing to increased energy expenditure and fuel mobilization. This was supported by findings that HFD-trans mice had greater energy expenditure during a norepinephrine challenge test and higher core temperatures after cold exposure than did HFD-sham mice, implicating enhanced whole-body metabolic response and elevated sympathetic activity. Additionally, transBATation selectively increased sympathetic drive to some, but not all, white adipose tissue depots and skeletal muscles, as well as the endogenous IBAT, heart, and liver. Collectively, transBATation confers resistance to HFD-induced obesity via increase in whole-body sympathetic activity, and differential activation of sympathetic drive to some of the tissues involved in energy expenditure and fuel mobilization.
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DOI：
10.1038/oby.2012.95
发表时间：
2012-07
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Harris RB
通讯作者：
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影响因子：
2.1
作者：
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通讯作者：
FRYDMAN, ML
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1152/ajpendo.00159.2011
发表时间：
2012-03-01
影响因子：
5.1
作者：
Holmstrom, Maria H.;Iglesias-Gutierrez, Eduardo;Garcia-Roves, Pablo M.
通讯作者：
Garcia-Roves, Pablo M.