Relationship between adult height and body weight and risk of carotid atherosclerosis assessed in terms of carotid intima-media thickness: the Nagasaki Islands study.
Relationship between adult height and body weight and risk of carotid atherosclerosis assessed in terms of carotid intima-media thickness: the Nagasaki Islands study.
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DOI：
10.1186/1880-6805-32-19
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发表时间：
2013-11-01
影响因子：
3.1
通讯作者：
Maeda T
中科院分区：
文献类型：
--
作者：
Shimizu Y;Nakazato M;Sekita T;Kadota K;Arima K;Yamasaki H;Goto H;Shirahama S;Takamura N;Aoyagi K;Maeda T
此前的研究报告称，身高与患心血管疾病的风险呈负相关。然而，关于动脉粥样硬化风险与身高之间的联系的证据有限。此外，尽管据称动脉粥样硬化与体重指数(BMI)呈正相关，但还没有关于身高和动脉粥样硬化与BMI之间关系的研究报告。我们对年龄在30岁到89岁之间的日本男性进行了一项横断面研究，这些男性正在接受全身健康检查。在1,337名男性中，有312人被诊断为颈动脉粥样硬化(颈动脉内中膜厚度( ≥ )1.1 mm)，但在整个研究组中，没有发现身高与颈动脉粥样硬化之间存在显著关联。这些分析结果按体重指数状况分层显示，在超重(体重指数 ≥ 为25公斤/平方米)的男性中，身高和颈动脉粥样硬化之间存在显著的负相关关系，但在非超重(体重指数为 <； 为25公斤/平方米)的男性中则不然。身高每增加1 SD(标准差)的经典心血管危险因素调整优势比(OR)和95%可信区间(CI)，超重(体重指数 ≥ 2 5 kg/m2)男性为0.71(0.5 4~0.94)，非超重(BMI <； 2 5 kg/m2)男性为1.0 5(0.87~1.2 7)。与经典的心血管危险因素无关，研究发现，超重男性的身高与颈动脉粥样硬化呈负相关，而非超重男性则不相关。
Previous studies have reported an inverse association between height and risk of cardiovascular disease. However, evidence is limited for the association between risk of atherosclerosis and height. Further, although the association between atherosclerosis and body mass index (BMI) is reportedly positive, there have been no reports of studies on associations between height and atherosclerosis in relation to BMI. We conducted a cross-sectional study of Japanese men aged 30 to 89 years undergoing general health check-ups. Of the 1,337 men, 312 were diagnosed with carotid atherosclerosis (carotid intima-media thickness (CIMT) ≥ 1.1 mm), but no significant association was found between height and carotid atherosclerosis for the entire study group. Stratification by BMI status of those analytical findings disclosed a significant inverse association between height and carotid atherosclerosis among overweight (BMI ≥ 25 kg/m2) but not among non-overweight (BMI < 25 kg/m2) men. The classical cardiovascular risk factors-adjusted odds ratio (OR) and 95% confidence interval (CI) of carotid atherosclerosis for an increment of one SD (standard deviation) in height (6.70 cm) were 0.71 (0.54 to 0.94) for overweight (BMI ≥ 25 kg/m2) and 1.05 (0.87 to 1.27) for non-overweight (BMI < 25 kg/m2) men. Independent from classical cardiovascular risk factors, height was found to be inversely associated with carotid atherosclerosis for overweight but not for non-overweight men.
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