Mapping interference resolution across task domains: a shared control process in left inferior frontal gyrus.

Mapping interference resolution across task domains: a shared control process in left inferior frontal gyrus.
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DOI:
10.1016/j.brainres.2008.12.001
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发表时间:
2009-02-23
期刊:
影响因子:
2.9
通讯作者:
Jonides J
Jonides J
中科院分区:
医学3区
文献类型:
--
作者:
Nelson JK;Reuter-Lorenz PA;Persson J;Sylvester CY;Jonides J

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功能神经成像方面的研究已经将干扰分辨处理映射到左下额叶区域,用于言语工作记忆和各种语义处理任务。从这些不同的任务中识别的区域的接近表明存在共同的、域通用的干扰解决机制。目前的研究特别在被试内设计中测试了这一想法,使用fMRI来评估与语义提取任务(动词生成)和具有试验特定的主动干扰操作的词汇工作记忆任务(新近探测)中变量选择要求相关的激活。两个任务的高干扰试验都与左下额下回腹外侧区的活动有关,并且每个任务中激活的区域强烈重叠。结果表明,在提取工作记忆和语义记忆的过程中,与干扰解决相关的执行控制的基本成分可以被映射到左额下回的一个共同部分。
Work in functional neuroimaging has mapped interference resolution processing onto left inferior frontal regions for both verbal working memory and a variety of semantic processing tasks. The proximity of the identified regions from these different tasks suggests the existence of a common, domain-general interference resolution mechanism. The current research specifically tests this idea in a within-subject design using fMRI to assess the activation associated with variable selection requirements in a semantic retrieval task (verb generation) and a verbal working memory task with a trial-specific proactive interference manipulation (recent-probes). High interference trials on both tasks were associated with activity in the midventrolateral region of the left inferior frontal gyrus, and the regions activated in each task strongly overlapped. The results indicate that an elemental component of executive control associated with interference resolution during retrieval from working memory and from semantic memory can be mapped to a common portion of the left inferior frontal gyrus.
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