Cortical thickness in neuropsychologically near-normal schizophrenia.
Cortical thickness in neuropsychologically near-normal schizophrenia.
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DOI：
10.1016/j.schres.2011.08.017
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发表时间：
2011-12
影响因子：
4.5
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
Cobia, Derin J.;Csernansky, John G.;Wang, Lei
精神分裂症是一种严重的精神疾病，具有广泛的认知功能障碍;然而，已知一定比例的受试者在神经心理学测量方面表现在正常范围内。虽然这些人的认知概况已被检查，有相对较少的关注，这一重要的亚组的神经解剖学特征。本研究的目的是统计识别认知相对正常的精神分裂症受试者，检查他们的神经解剖学特征，相对于他们更受损的同行使用皮层厚度映射，并调查这些特征和人口统计学变量之间的关系，以更好地了解精神分裂症的认知异质性的性质。收集了精神分裂症（n=79）和健康受试者（n=65）的临床、神经心理学和MRI数据。一系列的聚类算法的神经心理评分进行了检查，和2-集群的解决方案，分为神经心理接近正常（NPNN）和神经心理受损（NPI）组的对象被确定为最合适的。基于表面的皮质厚度映射被用来检查与健康参与者相比，精神分裂症亚型之间的变薄的差异。一个广泛的皮质变薄模式的精神分裂症的特点出现在NPI组，而NPNN的主题表现出非常有限的变薄相对于健康的比较对象。疾病持续时间的分析表明亚型分类和皮质厚度结果的影响最小。研究结果表明，精神分裂症患者的认知障碍和皮质变薄之间存在密切联系，其中认知能力接近正常的受试者也表现出接近正常的皮质厚度模式。虽然一般支持不同的病因过程的认知亚型，结果提供了进一步检查的其他神经解剖学差异的方向。
Schizophrenia is a severe psychiatric illness with widespread impairments of cognitive functioning; however, a certain percentage of subjects are known to perform in the normal range on neuropsychological measures. While the cognitive profiles of these individuals have been examined, there has been relatively little attention to the neuroanatomical characteristics of this important subgroup. The aims of this study were to statistically identify schizophrenia subjects with relatively normal cognition, examine their neuroanatomical characteristics relative to their more impaired counterparts using cortical thickness mapping, and to investigate relationships between these characteristics and demographic variables to better understand the nature of cognitive heterogeneity in schizophrenia. Clinical, neuropsychological, and MRI data were collected from schizophrenia (n=79) and healthy subjects (n=65). A series of clustering algorithms on neuropsychological scores was examined, and a 2-cluster solution that separated subjects into neuropsychologically near-normal (NPNN) and neuropsychologically impaired (NPI) groups was determined most appropriate. Surface-based cortical thickness mapping was utilized to examine differences in thinning among schizophrenia subtypes compared with the healthy participants. A widespread cortical thinning pattern characteristic of schizophrenia emerged in the NPI group, while NPNN subjects demonstrated very limited thinning relative to healthy comparison subjects. Analysis of illness duration indicated minimal effects on subtype classification and cortical thickness results. Findings suggest a strong link between cognitive impairment and cortical thinning in schizophrenia, where subjects with near-normal cognitive abilities also demonstrate near-normal cortical thickness patterns. While generally supportive of distinct etiological processes for cognitive subtypes, results provide direction for further examination of additional neuroanatomical differences.
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影响因子：
17.7
作者：
Goldstein, G;Allen, DN;van Kammen, DP
通讯作者：
van Kammen, DP
DOI：
10.1017/s1355617798003531
发表时间：
1998-07-01
影响因子：
2.6
作者：
Goldstein, G;Allen, DN;Seaton, BE
通讯作者：
Seaton, BE
影响因子：
4.5
作者：
Hill, SK;Schuepbach, D;Sweeney, JA
通讯作者：
Sweeney, JA
影响因子：
4.5
作者：
Smith MJ;Barch DM;Csernansky JG
通讯作者：
Csernansky JG
影响因子：
1.9
作者：
Allen, DN;Seaton, BE;van Kammen, DP
通讯作者：
van Kammen, DP