Bridging the gap between schizophrenia and psychotic mood disorders: Relating neurocognitive deficits to psychopathology.
Bridging the gap between schizophrenia and psychotic mood disorders: Relating neurocognitive deficits to psychopathology.
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DOI：
10.1016/j.schres.2008.07.014
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发表时间：
2009-01
影响因子：
4.5
通讯作者：
Csernansky JG
中科院分区：
文献类型：
--
作者：
Smith MJ;Barch DM;Csernansky JG
精神分裂症和精神病性心境障碍之间的神经生物学关系还不清楚。神经认知缺陷已被描述在这两种类型的疾病，并已提出反映潜在的神经生物学功能障碍。研究神经认知功能和精神病理学之间的关系有助于阐明精神分裂症和精神性心境障碍之间的神经生物学关系。参与者包括72名DSM-IV精神分裂症患者，25名具有精神病特征的情感障碍或双相情感障碍患者，以及72名社区对照。标准化评分和神经认知和精神病理学的四个领域之间的相关性进行了检查。精神分裂症和精神病性心境障碍患者在神经认知功能和精神病理学的几个维度上得分相似。神经认知功能与精神病理学的关系在两组中相似。精神分裂症和精神病性心境障碍患者在神经认知功能和精神病理学的损伤水平以及疾病的两个维度之间的关系方面是相似的。这些结果表明，精神分裂症和精神病性心境障碍，如情感障碍和双相情感障碍与精神病性特征是在一个神经生物学连续体。
The neurobiological relationship between schizophrenia and psychotic mood disorders is not well understood. Neurocognitive deficits have been described in both types of disorders and have been proposed to reflect underlying neurobiological dysfunction. Examining the relationship between neurocognitive function and psychopathology could help illuminate the neurobiological relationship between schizophrenia and psychotic mood disorders. Participants included 72 individuals with DSM-IV schizophrenia, 25 individuals with schizoaffective disorder or bipolar disorder with psychotic features, and 72 community controls. Standardized scores and correlations between four domains of neurocognition and psychopathology were examined. Individuals with schizophrenia and psychotic mood disorders scored similarly on several dimensions of neurocognitive function and psychopathology. The relationships between neurocognitive function and psychopathology were similar in the two groups. Individuals with schizophrenia and psychotic mood disorders were similar in terms of both the level of impairment in neurocognitive function and psychopathology, as well as in the relationship between the two dimensions of illness. These results suggest that schizophrenia and psychotic mood disorders such as schizoaffective disorder and bipolar disorder with psychotic features are on a neurobiological continuum.
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