Tandem mass spectrometry for characterization of covalent adducts of DNA with anticancer therapeutics.
Tandem mass spectrometry for characterization of covalent adducts of DNA with anticancer therapeutics.
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DOI：
10.1002/mas.21363
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发表时间：
2013-07
影响因子：
6.6
通讯作者：
Brodbelt, Jennifer S.
中科院分区：
文献类型：
--
作者：
Silvestri, Catherine;Brodbelt, Jennifer S.
许多抗癌和抗菌药物的化疗活性源于它们与核酸底物的相互作用。这些配体中的一些与DNA相互作用，导致构象变化或对核酸靶点造成损害，最终改变关键DNA特异性酶的识别，干扰DNA转录或禁止复制，并终止细胞生长和增殖。设计和合成与核酸结合的配体是药物化学和药物研究的一个动态领域。对更具选择性和更有效的DNA相互作用抗癌化学疗法的追求同样催化了对敏感分析方法的需求，这些方法可以提供有关所产生的DNA加合物性质的结构信息，并提供对DNA/药物相互作用的机制途径以及对生物系统中细胞过程的影响的见解。本文综述了一系列串联质谱技术在DNA和抗癌配体之间形成的共价加合物表征中的应用。
The chemotherapeutic activities of many anticancer and antibacterial drugs arise from their interactions with nucleic acid substrates. Some of these ligands interact with DNA in a way that causes conformational changes or damage to the nucleic acid targets, ultimately altering recognition by key DNA-specific enzymes, interfering with DNA transcription or prohibiting replication, and terminating cell growth and proliferation. The design and synthesis of ligands that bind to nucleic acids remains a dynamic field in medicinal chemistry and pharmaceutical research. The quest for more selective and efficacious DNA-interactive anti-cancer chemotherapeutics has likewise catalyzed the need for sensitive analytical methods that can provide structural information about the nature of the resulting DNA adducts and provide insight into the mechanistic pathways of the DNA/drug interactions and the impact on the cellular processes in biological systems. This review focuses on the array of tandem mass spectrometric strategies developed and applied for characterization of covalent adducts formed between DNA and anti-cancer ligands.
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影响因子：
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通讯作者：
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