Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus.

Genomic surveillance uncovers a pandemic clonal lineage of the wheat blast fungus.
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DOI:
10.1371/journal.pbio.3002052
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发表时间:
2023-04
期刊:
影响因子:
9.8
通讯作者:
--
中科院分区:
生物学1区
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--
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小麦是最重要的粮食作物之一,正受到稻瘟病大流行的威胁。在这里,我们展示了小麦瘟疫真菌的克隆谱系在两次独立地从南美洲引入后最近传播到亚洲和非洲。通过基因组分析和实验室实验相结合,我们证明了具有十年历史的稻瘟病大流行谱系可以由 Rmg8 抗病基因控制,并且对甲氧基丙烯酸酯类杀菌剂敏感。然而,我们也强调了大流行克隆进化出对杀真菌剂不敏感的变体并与非洲谱系发生性重组的潜力。这强调了迫切需要进行基因组监测,以跟踪和减轻南美洲以外小麦瘟疫的传播,并指导小麦抗瘟疫的先发制育。最重要的粮食作物小麦正受到稻瘟病大流行的威胁。这项研究利用基因组分析来追踪流行性瘟疫真菌克隆谱系的传播,并揭示其进化出对杀菌剂不敏感的变体以及与非洲谱系进行有性重组的潜力。
Wheat, one of the most important food crops, is threatened by a blast disease pandemic. Here, we show that a clonal lineage of the wheat blast fungus recently spread to Asia and Africa following two independent introductions from South America. Through a combination of genome analyses and laboratory experiments, we show that the decade-old blast pandemic lineage can be controlled by the Rmg8 disease resistance gene and is sensitive to strobilurin fungicides. However, we also highlight the potential of the pandemic clone to evolve fungicide-insensitive variants and sexually recombine with African lineages. This underscores the urgent need for genomic surveillance to track and mitigate the spread of wheat blast outside of South America and to guide preemptive wheat breeding for blast resistance. Wheat, the most important food crop, is threatened by a blast disease pandemic. This study uses genome analyses to track the spread of a clonal lineage of the pandemic blast fungus and to reveal its potential to evolve fungicide-insensitive variants and sexually recombine with African lineages.
使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
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