Updating the list of known opioids through identification and characterization of the new opioid derivative 3,4-dichloro-N-(2-(diethylamino)cyclohexyl)-N-methylbenzamide (U-49900).
Updating the list of known opioids through identification and characterization of the new opioid derivative 3,4-dichloro-N-(2-(diethylamino)cyclohexyl)-N-methylbenzamide (U-49900).
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DOI：
10.1038/s41598-017-06778-9
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发表时间：
2017-07-24
影响因子：
4.6
通讯作者：
Ibáñez M
中科院分区：
文献类型：
--
作者：
Fabregat-Safont D;Carbón X;Ventura M;Fornís I;Guillamón E;Sancho JV;Hernández F;Ibáñez M
新型精神活性物质作为非非法药物在毒品市场上迅速流行。在过去几年中，据报告海洛因合成替代品即合成类阿片的使用有所增加。根据欧洲毒品和毒瘾监测中心提供的信息，这些合成类阿片与欧洲和北美的过量和死亡有关。其中一种阿片类药物是U-47700。几个月前，U-47700计划在美国和其他国家上市，为了取代它，其他阿片类衍生物已经出现。其中一种化合物是U-49900，U-47700的类似物。从西班牙的一位匿名用户那里获得了一份白色粉末样本。通过气相色谱-质谱联用、超高效液相色谱-高分辨质谱联用、核磁共振和单晶X-射线衍射等方法进行准确表征，并辅以傅立叶变换红外光谱、紫外和圆二色谱分光光度法，确定该药物样品为U-49900。所提供的信息将有助于预警系统和法医实验室今后识别U-49900，以及初步识别其他相关类阿片。
New psychoactive substances have been rapidly growing in popularity in the drug market as non-illegal drugs. In the last few years, an increment has been reported on the use of synthetic alternatives to heroin, the synthetic opioids. Based on the information provided by the European Monitoring Centre for Drug and Drug Addiction, these synthetic opioids have been related to overdoses and deaths in Europe and North America. One of these opioids is the U-47700. A few months ago, U-47700 was scheduled in the U.S. and other countries, and other opioid derivatives have been appearing in order to replace it. One of these compounds is U-49900, an analog of U-47700. A white powder sample was obtained from an anonymous user in Spain. After an accurate characterization by gas chromatography-mass spectrometry, ultra-high performance liquid chromatography-high resolution mass spectrometry, nuclear magnetic resonance and single-crystal X-ray diffraction; and complemented by Fourier-transformed infrared spectroscopy, ultraviolet and circular dichroism spectrophotometry, the drug sample was unequivocally identified as U-49900. The information provided will be useful for the Early Warning System and forensic laboratories for future identifications of the U-49900, as well as in tentative identifications of other related opioids.
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影响因子：
4.3
作者：
Alechaga, Elida;Moyano, Encarnacion;Teresa Galceran, Maria
通讯作者：
Teresa Galceran, Maria
影响因子：
3.3
作者：
Helander, A.;Backberg, M.;Beck, O.
通讯作者：
Beck, O.
影响因子：
4.3
作者：
Ibanez, Maria;Pozo, Oscar J.;Hernandez, Felix
通讯作者：
Hernandez, Felix
影响因子：
3
作者：
Fattore L;Fratta W
通讯作者：
Fratta W
影响因子：
2.9
作者：
Fabregat-Safont, D.;Fornis, I.;Ibanez, M.
通讯作者：
Ibanez, M.