Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China.
Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China.
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中国慢性砷中毒地区个体唾液和尿液样本的总砷和形态分析
DOI：
10.1186/s12199-017-0652-5
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发表时间：
2017-05-11
影响因子：
4.7
通讯作者：
An Y
中科院分区：
文献类型：
--
作者：
Wang D;Shimoda Y;Wang S;Wang Z;Liu J;Liu X;Jin H;Gao F;Tong J;Yamanaka K;Zhang J;An Y
背景一般认为，测定唾液中的有害化合物有助于评估其暴露水平。本研究的目的是比较唾液和尿中总砷及其形态的差异，进一步验证唾液砷作为砷暴露新生物标志物的可行性。结果唾液中总砷浓度相对低于尿液中总砷浓度，但与尿总砷、饮用水砷及不同皮肤病变呈强正相关。砷代谢分析中，砷III，砷V，MMA，和DMA检测在所有的尿液样本中的DMA（73.2%）的主导物种。与尿砷形态不同，唾液中绝大多数砷形态未发生甲基化。唾液中的主要种类为iAs（AsIII+ AsV，76.18%），其次为DMA（13.08%）和MMA（9.13%）。以及一级甲基化指数（PMI）、二级甲基化指数（SMI）和四种不同物种所占比例（AsIII，AsV，MMA，（DMA）结论唾液可作为人群总砷暴露的生物学监测工具，而不是评价砷暴露后人体砷代谢的有效工具。接触砷。
BackgroundIt is generally acknowledged that the determination of harmful chemical compounds excreted into saliva is useful for assessing their exposure levels. The aim of the present study was to compare the total arsenic and its species in saliva and urine samples collected from the people residing in an arsenic-contaminated area of China and to further verify the feasibility of using salivary arsenic as a new biomarker of arsenic exposure.MethodsTotal arsenic and speciation analyses in urine and saliva samples among 70 residents exposed to arsenic from drinking water in Shanxi, China were carried out by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP/MS).ResultsThe result showed that, total arsenic concentration in saliva was relatively lower than in urine samples, but it existed a strong positive correlation with total urinary arsenic, drinking water arsenic and different skin lesions. For arsenic metabolism analyses, AsIII, AsV, MMA, and DMA were detected in all of the urine samples with the dominating species of DMA (73.2%). Different with urinary arsenic species, most arsenic species in saliva were not methylated. The major species in saliva was iAs (AsIII+ AsV, 76.18%), followed by DMA (13.08%) and MMA (9.13%). And the primary methylation index (PMI), second methylation index (SMI) and proportion of the four different species (AsIII, AsV, MMA, and DMA) in saliva showed no significant positive relationship with that of in urine.ConclusionsThese findings indicated saliva may be used as a useful tool for biological monitoring of total arsenic exposure in the crowd rather than an efficient tool for assessing arsenic metabolism in human body after exposed to arsenic.
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