Breast-feeding protects against arsenic exposure in Bangladeshi infants.
Breast-feeding protects against arsenic exposure in Bangladeshi infants.
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DOI：
10.1289/ehp.11094
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发表时间：
2008-07
影响因子：
10.4
通讯作者：
Vahter, Marie
中科院分区：
文献类型：
--
作者：
Fangstrom, Britta;Moore, Sophie;Nermell, Barbro;Kuenstl, Linda;Goessler, Walter;Grander, Margaretha;Kabir, Iqbal;Palm, Brita;El Arifeen, Shams;Vahter, Marie
慢性砷暴露会引起广泛的健康影响，但对暴露的关键窗口知之甚少。砷很容易穿过胎盘，但关于出生后通过母乳接触砷的少数可用数据并不确定。我们的目标是评估孟加拉国婴儿通过母乳接触砷的情况，这些婴儿生活在一个富含砷的管井水流行率很高的地区。我们分析了3个月大时母乳和婴儿尿液中无机砷的代谢产物，并将其与母乳喂养实践和母亲砷暴露的详细信息进行了比较，这些信息通过血液，尿液和唾液中的浓度进行测量。母乳样本中的砷浓度很低（中位数为1微克/千克;范围为0.25-19微克/千克），尽管通过饮用水接触砷的程度很高（尿液中为10- 1，100微克/升，红细胞中为2-40微克/升）。因此，母亲报告纯母乳喂养的婴儿尿中砷浓度较低（中位数为1.1微克/升;范围为0.3-29微克/升），而母亲报告部分母乳喂养的婴儿尿中砷浓度范围为0.4 - 1，520微克/升（中位数为1.9微克/升）。牛奶中的砷主要是无机砷。尽管如此，婴儿尿液中的二甲基化砷代谢物的比例很高（中位数为87%）。母乳中的砷与母亲血液、尿液和唾液中的砷有关。母乳中排出的砷很少，即使是饮用水暴露量高的妇女。因此，纯母乳喂养可保护婴儿免受砷的影响。
Chronic arsenic exposure causes a wide range of health effects, but little is known about critical windows of exposure. Arsenic readily crosses the placenta, but the few available data on postnatal exposure to arsenic via breast milk are not conclusive. Our goal was to assess the arsenic exposure through breast milk in Bangladeshi infants, living in an area with high prevalence of arsenic-rich tube-well water. We analyzed metabolites of inorganic arsenic in breast milk and infant urine at 3 months of age and compared them with detailed information on breast-feeding practices and maternal arsenic exposure, as measured by concentrations in blood, urine, and saliva. Arsenic concentrations in breast-milk samples were low (median, 1 μg/kg; range, 0.25–19 μg/kg), despite high arsenic exposures via drinking water (10–1,100 μg/L in urine and 2–40 μg/L in red blood cells). Accordingly, the arsenic concentrations in urine of infants whose mothers reported exclusive breast-feeding were low (median, 1.1 μg/L; range, 0.3–29 μg/L), whereas concentrations for those whose mothers reported partial breast-feeding ranged from 0.4 to 1,520 μg/L (median 1.9 μg/L). The major part of arsenic in milk was inorganic. Still, the infants had a high fraction (median, 87%) of the dimethylated arsenic metabolite in urine. Arsenic in breast milk was associated with arsenic in maternal blood, urine, and saliva. Very little arsenic is excreted in breast milk, even in women with high exposure from drinking water. Thus, exclusive breast-feeding protects the infant from exposure to arsenic.
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DOI：
10.1186/1476-069x-5-31
发表时间：
2006-10-31
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Dakeishi M;Murata K;Grandjean P
通讯作者：
Grandjean P
影响因子：
8.3
作者：
Calderón, J;Navarro, ME;Díaz-Barriga, F
通讯作者：
Díaz-Barriga, F
DOI：
10.1007/s004200050248
发表时间：
1998-02-01
影响因子：
3
作者：
Concha, G;Vogler, G;Vahter, M
通讯作者：
Vahter, M
影响因子：
10.4
作者：
Hopenhayn-Rich, C;Browning, SR;Gibb, H
通讯作者：
Gibb, H
DOI：
10.1097/jom.0b013e3181566ba0
发表时间：
2007-10-01
影响因子：
3.2
作者：
Huyck, Karen L.;Kile, Molly L.;Christiani, David C.
通讯作者：
Christiani, David C.