A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA.
A population-based case-control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA.
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DOI：
10.1289/ehp.1206178
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发表时间：
2013-10
影响因子：
10.4
通讯作者：
Karagas MR
中科院分区：
文献类型：
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作者：
Gilbert-Diamond D;Li Z;Perry AE;Spencer SK;Gandolfi AJ;Karagas MR
背景：慢性高砷暴露与皮肤鳞状细胞癌（SCC）有关，无机砷（iAs）代谢物可能在这一关联中起重要作用。然而，人们对砷在美国普遍观察到的致癌性所知甚少。目的：我们估计美国人群尿中总砷和砷种类与鳞状细胞癌之间的关系。方法：我们在美国一个地区进行了一项基于人群的病例对照SCC研究（470例，447例对照），该地区通过私人井水和饮食适度暴露于砷。我们测量了尿砷、一甲基拉森酸（MMA）和二甲基拉森酸（DMA），并总结了这些砷的种类（ΣAs）。由于海鲜含有通过其他途径代谢为DMA的砷脂和砷糖，因此在尿液收集前2天内报告海鲜消费的参与者被排除在分析之外。结果：在调整后的logistic回归分析（323例，319例对照）中，ln转化ΣAs浓度每增加1微克/升，SCC优势比（OR）为1.37 （95% CI: 1.04, 1.80）。尿ln（MMA）和ln（DMA）也与SCC呈正相关（OR = 1.34； 95% CI分别为1.04、1.71和OR = 1.34； 95% CI分别为1.03、1.74）。ln（iAs）也有类似的趋势（OR = 1.20; 95% CI: 0.97, 1.49）。百分比的iAs、MMA和DMA与SCC无关。结论：这些结果表明，在美国，砷暴露水平与SCC有关，而砷代谢能力并不改变这种关联。引用本文：Gilbert-Diamond D， Li Z, Perry AE, Spencer SK, Gandolfi AJ, Karagas MR. 2013。美国新罕布什尔州尿砷种类与鳞状细胞癌的一项基于人群的病例对照研究。环境健康展望121:1154-1160；http://dx.doi.org/10.1289/ehp.1206178
Background: Chronic high arsenic exposure is associated with squamous cell carcinoma (SCC) of the skin, and inorganic arsenic (iAs) metabolites may play an important role in this association. However, little is known about the carcinogenicity of arsenic at levels commonly observed in the United States. Objective: We estimated associations between total urinary arsenic and arsenic species and SCC in a U.S. population. Methods: We conducted a population-based case–control SCC study (470 cases, 447 controls) in a U.S. region with moderate arsenic exposure through private well water and diet. We measured urinary iAs, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA), and summed these arsenic species (ΣAs). Because seafood contains arsenolipids and arsenosugars that metabolize into DMA through alternate pathways, participants who reported seafood consumption within 2 days before urine collection were excluded from the analyses. Results: In adjusted logistic regression analyses (323 cases, 319 controls), the SCC odds ratio (OR) was 1.37 for each ln-transformed microgram per liter increase in ln-transformed ΣAs concentration [ln(ΣAs)] (95% CI: 1.04, 1.80). Urinary ln(MMA) and ln(DMA) also were positively associated with SCC (OR = 1.34; 95% CI: 1.04, 1.71 and OR = 1.34; 95% CI: 1.03, 1.74, respectively). A similar trend was observed for ln(iAs) (OR = 1.20; 95% CI: 0.97, 1.49). Percent iAs, MMA, and DMA were not associated with SCC. Conclusions: These results suggest that arsenic exposure at levels common in the United States relates to SCC and that arsenic metabolism ability does not modify the association. Citation: Gilbert-Diamond D, Li Z, Perry AE, Spencer SK, Gandolfi AJ, Karagas MR. 2013. A population-based case–control study of urinary arsenic species and squamous cell carcinoma in New Hampshire, USA. Environ Health Perspect 121:1154–1160; http://dx.doi.org/10.1289/ehp.1206178
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影响因子：
10.4
作者：
Applebaum KM;Karagas MR;Hunter DJ;Catalano PJ;Byler SH;Morris S;Nelson HH
通讯作者：
Nelson HH
影响因子：
1.8
作者：
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通讯作者：
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影响因子：
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DOI：
10.1016/s1383-5742(97)00003-3
发表时间：
1997-06-01
影响因子：
5.3
作者：
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通讯作者：
Doerr, CL
影响因子：
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