Sleep loss and inflammation.
Sleep loss and inflammation.
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DOI：
10.1016/j.beem.2010.08.014
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发表时间：
2010-10
期刊：
影响因子：
--
通讯作者：
Haack M
中科院分区：
文献类型：
--
作者：
Mullington JM;Simpson NS;Meier-Ewert HK;Haack M
对人类急性睡眠不足影响的对照实验研究表明，睡眠不足会改变炎症介质。这些介质的升高已被发现发生在经历超过24小时的实验性守夜的健康、严格筛选的个体中，并且还被观察到对限制在正常8小时睡眠量的25%至50%之间的各种睡眠持续时间的响应。虽然这些改变的谱代表小的变化，但已知基础炎性细胞因子的这种亚临床变化与健康无症状个体中代谢综合征疾病的未来发展相关。虽然在经历实验性睡眠丧失的人类中这种改变的炎症状态的机制尚不清楚，但自主激活和代谢变化可能起着关键作用。
Controlled, experimental studies on the effects of acute sleep loss in humans have shown that mediators of inflammation are altered by sleep loss. Elevations in these mediators have been found to occur in healthy, rigorously screened individuals undergoing experimental vigils of more than 24 hours, and have also been seen in response to various durations of sleep restricted to between 25 and 50% of a normal 8 hour sleep amount. While these altered profiles represent small changes, such sub-clinical shifts in basal inflammatory cytokines are known to be associated with the future development of metabolic syndrome disease in healthy, asymptomatic individuals. Although the mechanism of this altered inflammatory status in humans undergoing experimental sleep loss is unknown, it is likely that autonomic activation and metabolic changes play key roles.
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影响因子：
3.7
作者：
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通讯作者：
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