Sarcopenia prevalence and associated factors among older Chinese population: Findings from the China Health and Retirement Longitudinal Study.
Sarcopenia prevalence and associated factors among older Chinese population: Findings from the China Health and Retirement Longitudinal Study.
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DOI：
10.1371/journal.pone.0247617
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Wu X;Li X;Xu M;Zhang Z;He L;Li Y
肌肉减少症是一种公认的老年综合征。本研究旨在评估中国老年人中可能的肌肉减少症、肌肉减少症和重度肌肉减少症的患病率，并根据2019年亚洲肌肉减少症工作组（AWGS 2019）更新的诊断标准确定可能的肌肉减少症的任何相关因素。我们使用了中国健康与退休纵向研究（CHARLS）的数据。本研究的主要结果是可能出现肌肉减少症。通过测力计测量握力。通过人体测量法估计肌肉质量。体能测试采用5次椅立试验和步态速度试验。采用多元Logistic回归模型逐步分析可能与肌肉减少症相关的因素。共纳入6172名年龄在60-94岁之间的参与者。可能性少肌症、少肌症和重度少肌症的患病率分别为38.5%、18.6%和8.0%。年龄、农村地区、福尔斯、较高的C反应蛋白（CRP）和慢性疾病（包括高血压、慢性肺病、心脏病、精神疾病和关节炎）与可能的肌肉减少症的较高风险相关。相反，饮酒、较高的步态速度和高水平的血红蛋白与可能的肌肉减少症的风险降低有关。然而，Bonferroni校正后，可能的肌肉减少症与饮酒、心脏病、精神病和血红蛋白之间的关联并不显著。我们的研究报告了中国老年人群中肌肉减少症的相对高患病率，并确定了一系列与肌肉减少症相关的因素。我们还发现农村老年人比城市老年人更容易患肌肉减少症。此外，我们发现全身炎症可能是肌肉减少症和相关合并症之间的影响因素之一。我们相信这项研究的结果将有助于早期识别肌肉减少症的高危人群，从而实施预防和治疗策略，以减少中国的疾病负担。
Sarcopenia a recognised geriatric syndrome. This study aims to evaluate the prevalence of possible sarcopenia, sarcopenia and severe sarcopenia among older Chinese adults and to identify any associated factors for possible sarcopenia according to the updated diagnostic criteria of the Asian Working Group for Sarcopenia 2019 (AWGS 2019). We used data from the China Health and Retirement Longitudinal Study (CHARLS). The main outcome of this study was possible sarcopenia. Handgrip strength was measured via a dynamometer. The muscle mass was estimated by anthropometric measures. Physical performance was measured by 5-time chair stand test and gait speed test. A multivariate logistic regression model with stepwise method was employed to identify factors associated with possible sarcopenia. A total of 6172 participants aged 60–94 years were included. The prevalence of possible sarcopenia, sarcopenia and severe sarcopenia was 38.5%, 18.6%, and 8.0%, respectively. Age, rural area, falls, higher C-reactive protein (CRP), and chronic diseases (including hypertension, chronic lung diseases, heart disease, psychiatric disease and arthritis) were associated with a higher risk of possible sarcopenia. Conversely, alcohol consumption, higher gait speed and high levels of hemoglobin were associated with decreased risk of possible sarcopenia. However, the associations between possible sarcopenia with alcohol consumption, heart disease, psychiatric disease and hemoglobin were not significant after Bonferroni correction. Our study reported a relatively high prevalence of sarcopenia among older Chinese population, and identified a range of factors associated with sarcopenia. We also found rural elders are more vulnerable to sarcopenia than urban elders. Additionally, we discovered systemic inflammation might be one of the contributing factors between sarcopenia and related comorbidities. We believe the findings of this study would help to identify individuals at high risk of sarcopenia early and therefore implement the prevention and treatment strategies to reduce the disease burden in China.
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影响因子：
4.1
作者：
Limpawattana P;Inthasuwan P;Putraveephong S;Boonsawat W;Theerakulpisut D;Sawanyawisuth K
通讯作者：
Sawanyawisuth K
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
DOI：
10.1093/gerona/glp148
发表时间：
2010-03-01
影响因子：
5.1
作者：
Haren, Matthew T.;Malmstrom, Theodore K.;Morley, John E.
通讯作者：
Morley, John E.
使用 AWGS 定义，居住在郊区的中国老年人有心血管危险因素的患者患肌少症的风险增加
影响因子：
4.6
作者：
Han P;Yu H;Ma Y;Kang L;Fu L;Jia L;Chen X;Yu X;Hou L;Wang L;Zhang W;Yin H;Niu K;Guo Q
通讯作者：
Guo Q
影响因子：
3.7
作者：
Han K;Park YM;Kwon HS;Ko SH;Lee SH;Yim HW;Lee WC;Park YG;Kim MK;Park YM
通讯作者：
Park YM