Effects of coenzyme Q10 supplementation on activities of selected antioxidative enzymes and lipid peroxidation in hypertensive patients treated with indapamide. A pilot study.
Effects of coenzyme Q10 supplementation on activities of selected antioxidative enzymes and lipid peroxidation in hypertensive patients treated with indapamide. A pilot study.
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DOI：
10.5114/aoms.2010.14461
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发表时间：
2010-08-30
期刊：
影响因子：
--
通讯作者：
Rysz J
中科院分区：
文献类型：
--
作者：
Kędziora-Kornatowska K;Czuczejko J;Motyl J;Szewczyk-Golec K;Kozakiewicz M;Pawluk H;Kędziora J;Błaszczak R;Banach M;Rysz J
在高血压患者中，氧化应激的增加得到了有力的证明。在血管中，氧化应激增加了与一氧化氮（NO）反应的超氧阴离子（O2•−）的产生，损害了内皮细胞放松的能力。许多报道表明辅酶Q10 （CoQ）对高血压有有益作用。辅酶Q10治疗可降低O2•−，从而减少高血压相关并发症。本研究的目的是评估补充CoQ对老年高血压患者抗氧化酶活性和脂质过氧化的影响。我们测定了27例接受吲达帕胺治疗的老年高血压患者（平均年龄72.5±6.1岁）的红细胞超氧化物歧化酶（SOD-1）和谷胱甘肽过氧化物酶（GSH-Px）的活性和丙二醛（MDA）的浓度，并与30名健康老年志愿者（平均年龄76.8±8.5岁）进行了对比。与健康志愿者相比，补充前高血压患者SOD-1水平降低（p < 0.001）， GSH-Px活性降低和MDA水平升高（p < 0.001）不显著。辅酶Q10只导致SOD-1活性显著升高（p < 0.001）。目前的研究表明，CoQ改善了抗氧化防御系统中最重要的成分- SOD-1，它负责清除O2•−。辅酶Q10可作为预防和治疗老年高血压患者的附加治疗剂。
An increase in oxidative stress is strongly documented in hypertensive patients. In blood vessels, oxidative stress increases the production of superoxide anion (O2•−) that reacts with nitric oxide (NO) and impairs the ability of endothelium to relax. Many reports indicate a beneficial effect of coenzyme Q10 (CoQ) in hypertension. Coenzyme Q10 therapy may lower O2•− and thus decrease the complications associated with hypertension. The aim of our study was to evaluate the effects of CoQ supplementation on antioxidative enzyme activities and lipid peroxidation in elderly hypertensive patients. We determined the activities of superoxide dismutase (SOD-1) and glutathione peroxidase (GSH-Px) and the concentration of malondialdehyde (MDA) in erythrocytes of 27 elderly (mean age 72.5 ±6.1 year) hypertensive patients treated with indapamide at baseline and after 12 weeks of CoQ supplementation (60 mg twice a day) in comparison with 30 healthy elderly volunteers (mean age 76.8 ±8.5 year). Decrease of SOD-1 (p < 0.001) and insignificant reduction of GSH-Px activities and increase of MDA (p < 0.001) level were observed in hypertensive patients in comparison to healthy volunteers before supplementation. Coenzyme Q10 administration resulted in a significant increase only in SOD-1 activity (p < 0.001). The present study indicates that CoQ improves the most important component of the antioxidant defence system – SOD-1, which is responsible for O2•− scavenging. Coenzyme Q10 may be used as an additional therapeutic agent for prophylaxis and treatment of hypertension in elderly patients.
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DOI：
10.2170/jjphysiol.52.435
发表时间：
2002-10-01
期刊：
JAPANESE JOURNAL OF PHYSIOLOGY
影响因子：
--
作者：
Donmez, G;Derici, U;Hasanoglu, E
通讯作者：
Hasanoglu, E
影响因子：
5.3
作者：
Kontush, A;Reich, A;Beisiegel, U
通讯作者：
Beisiegel, U
影响因子：
56.9
作者：
FRIDOVICH, I
通讯作者：
FRIDOVICH, I
DOI：
10.1016/j.ejpb.2007.03.010
发表时间：
2007-09-01
影响因子：
4.9
作者：
Ankola, D. D.;Viswanad, B.;Kumar, M. N. V. Ravi
通讯作者：
Kumar, M. N. V. Ravi
影响因子：
2.9
作者：
PLACER, ZA;CUSHMAN, LL;JOHNSON, BC
通讯作者：
JOHNSON, BC