Terahertz metal-graphene hybrid metamaterial for monitoring aggregation of Aβ16-22 peptides
Terahertz metal-graphene hybrid metamaterial for monitoring aggregation of Aβ16-22 peptides
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太赫兹金属石墨烯混合超材料用于监测 Aβ16-22 肽的聚集
DOI：
10.1016/j.snb.2022.132016
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发表时间：
2022-05
影响因子：
8.4
通讯作者：
Xiaohua Deng
中科院分区：
文献类型：
--
作者：
Ling Xu;Jianwei Xu;Wencan Liu;Dongdong Lin;Jiangtao Lei;Binbin Zhou;Yun Shen;Xiaohua Deng
淀粉样蛋白（a β）聚集成淀粉样原纤维是阿尔茨海默病的一个主要标志。检测Aβ聚集对本病的早期诊断具有重要意义。在这里，我们提出了一种新的太赫兹金属-石墨烯杂化超材料来监测Aβ 16-22肽的纤化。我们证明了在混合超材料传感器上形成具有两个不同光谱透射峰的拉比分裂模式。石墨烯电子掺杂和费米能级在α 16-22多肽聚集形成的不同阶段有所不同。由于石墨烯费米能级的变化导致了Rabi分裂峰的移动，通过监测Rabi分裂峰的位置，我们可以非常灵敏地监测到Aβ 16-22肽的聚集过程。此外，我们在原子水平上的分子动力学模拟表明，石墨烯电子掺杂的变化是由于石墨烯与α β 16-22肽在聚集过程中π-π堆积的减少引起的。通过成功地将费米能级位移与移位的拉比分裂峰连接起来，所展示的新型传感器为一种新型简单，无标签，高灵敏度的混合石墨烯超材料传感方案铺平了道路，可用于阿尔茨海默病的检测和更广泛的应用。•提出了一种基于拉比分裂的新型太赫兹金属-石墨烯杂化超材料。•通过连接石墨烯费米水平和拉比分裂峰，可以灵敏地监测β 16-22肽的纤化。与纯金属传感器不同，我们的传感器在石墨烯和目标肽之间通过π-π堆叠呈现特异性结合。•通过分子动力学模拟揭示了原子水平上的传感机制。
The aggregation of amyloid-beta (Aβ) protein into amyloid fibrils represents a major hallmark of Alzheimer's disease. Detection of Aβ aggregation has great significance for early diagnosis of the disease. Here, we propose one novel Terahertz metal-graphene hybrid metamaterial to monitor the fibrillization of Aβ 16–22 peptides. We demonstrate the formation of Rabi splitting modes with two distinctive spectral transmission peaks on the hybrid metamaterial sensor. Graphene electron doping and Fermi energy level vary in different phases of Aβ 16–22 peptides aggregation formation. As change on graphene Fermi level leads to the shifting of the Rabi splitting peaks, by monitoring the position of Rabi splitting peaks, we can very sensitively monitor the Aβ 16–22 peptides aggregation process. Moreover, our molecular dynamics simulations at the atomic level reveal that the variation of graphene electron doping is caused by the reduction of π-π stacking between graphene and Aβ 16–22 peptides in aggregation process. By successfully linking the Fermi level shift to the shifting Rabi splitting peaks, the demonstrated novel sensor paves the way for a new type of simple, label-free, and highly sensitive hybrid graphene metamaterial sensing scheme for Alzheimer’s detection and broader applications. • A novel terahertz metal-graphene hybrid metamaterial basing on Rabi splitting is proposed. • The fibrillization of Aβ 16–22 peptides is sensitively monitored by linking graphene Fermi level to Rabi splitting peaks. • Difference to pure metal sensors, our sensor presents specific binding by π-π stacking between graphene and target peptide. • The sensing mechanisms at the atomic level are revealed through molecular dynamics simulations.
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影响因子：
15
作者：
Liang, Chen;Ni, Rong;Lynn, David G.
通讯作者：
Lynn, David G.
使用石墨烯超材料异质结构平台进行太赫兹生物传感
影响因子：
10.9
作者：
Xu, Wendao;Xie, Lijuan;Ying, Yibin
通讯作者：
Ying, Yibin
影响因子：
5.7
作者：
Sethi, Jagriti;Van Bulck, Michiel;Pan, Genhua
通讯作者：
Pan, Genhua
DOI：
10.1002/asia.201501355
发表时间：
2016-03
期刊：
Chemistry, an Asian journal
影响因子：
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作者：
Yanli Zhou;Lantao Liu;Yuanqiang Hao;Maotian Xu
通讯作者：
Yanli Zhou;Lantao Liu;Yuanqiang Hao;Maotian Xu
氮掺杂石墨烯及其在电化学生物传感中的应用
影响因子：
17.1
作者：
Wang, Ying;Shao, Yuyan;Lin, Yuehe
通讯作者：
Lin, Yuehe