The malaria-infected red blood cell: structural and functional changes.
The malaria-infected red blood cell: structural and functional changes.
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DOI：
10.1016/s0065-308x(01)50029-9
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发表时间：
2001
影响因子：
--
通讯作者：
Coppel RL
中科院分区：
文献类型：
--
作者：
Cooke BM;Mohandas N;Coppel RL
疟原虫属疟原虫的无性阶段侵入包括人类在内的各种物种的红细胞。在寄生虫入侵后，红细胞逐渐获得一组新的性质，并通过红细胞胞质中新结构的出现和红细胞膜骨架中新蛋白的出现，转化为更典型的（尽管更简单）真核细胞。红细胞经历显著的形态学改变，其流变学性质显著改变，表现为红细胞具有增加的膜刚性、降低的变形性和增加的对许多其他细胞（包括血管内皮）的粘附性。阐明寄生虫入侵和成熟引起的红细胞结构变化，并了解伴随的功能改变，有能力大大扩展我们的知识，在正常红细胞的结构-功能关系。此外，干扰这些相互作用可能会导致以前未被怀疑的手段，降低寄生虫的毒力，并可能导致新的抗疟治疗的发展。
The asexual stage of malaria parasites of the genus Plasmodium invade red blood cells of various species including humans. After parasite invasion, red blood cells progressively acquire a new set of properties and are converted into more typical, although still simpler, eukaryotic cells by the appearance of new structures in the red blood cell cytoplasm, and new proteins at the red blood cell membrane skeleton. The red blood cell undergoes striking morphological alterations and its rheological properties are considerably altered, manifesting as red blood cells with increased membrane rigidity, reduced deformability and increased adhesiveness for a number of other cells including the vascular endothelium. Elucidation of the structural changes in the red blood cell induced by parasite invasion and maturation and an understanding of the accompanying functional alterations have the ability to considerably extend our knowledge of structure-function relationships in the normal red blood cell. Furthermore, interference with these interactions may lead to previously unsuspected means of reducing parasite virulence and may lead to the development of novel antimalarial therapeutics.
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影响因子：
2.1
作者：
AIKAWA, M;TORII, M;MILLER, LH
通讯作者：
MILLER, LH
DOI：
10.4269/ajtmh.1985.34.45
发表时间：
1985-01-01
影响因子：
3.3
作者：
AIKAWA, M;RABBEGE, J;MILLER, LH
通讯作者：
MILLER, LH
影响因子：
1.5
作者：
Barale, JC;AttalBonnefoy, G;Langsley, G
通讯作者：
Langsley, G
影响因子：
20.3
作者：
Angus, BJ;Chotivanich, K;White, NJ
通讯作者：
White, NJ
影响因子：
2.1
作者：
Aikawa, M;Kamanura, K;Tandler, B
通讯作者：
Tandler, B