Platelet-Derived Microvesicles in Cardiovascular Diseases.
Platelet-Derived Microvesicles in Cardiovascular Diseases.
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DOI：
10.3389/fcvm.2017.00074
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发表时间：
2017
影响因子：
3.6
通讯作者：
Peter K
中科院分区：
文献类型：
--
作者：
Zaldivia MTK;McFadyen JD;Lim B;Wang X;Peter K
在血液中循环的微泡（MV）是源自细胞（例如活化的血小板、内皮细胞和白细胞）的膜泡的小泡（直径100- 1，000 nm）。越来越多的证据支持血小板衍生微泡（PMV）是循环中最丰富的MV，是止血、炎症和血管生成的重要调节因子。与健康个体相比，已观察到循环PMV的大幅增加，特别是在心血管疾病患者中。如在来自其他亲本细胞的MV中所观察到的，PMV以多种方式发挥其生物学效应，例如触发各种细胞间信号传导级联，以及通过将其细胞质组分和表面受体的“货物”转移到其他细胞类型来参与跨细胞通信。本文综述了我们目前对PMV在介导止血、炎症和血管生成中的潜在作用及其对心血管疾病（如动脉粥样硬化、心肌梗死和静脉血栓形成）发病机制的影响的认识。此外，将讨论PMVs治疗心血管疾病的治疗潜力的新发展。
Microvesicles (MVs) circulating in the blood are small vesicles (100–1,000 nm in diameter) derived from membrane blebs of cells such as activated platelets, endothelial cells, and leukocytes. A growing body of evidence now supports the concept that platelet-derived microvesicles (PMVs), the most abundant MVs in the circulation, are important regulators of hemostasis, inflammation, and angiogenesis. Compared with healthy individuals, a large increase of circulating PMVs has been observed, particularly in patients with cardiovascular diseases. As observed in MVs from other parent cells, PMVs exert their biological effects in multiple ways, such as triggering various intercellular signaling cascades and by participating in transcellular communication by the transfer of their “cargo” of cytoplasmic components and surface receptors to other cell types. This review describes our current understanding of the potential role of PMVs in mediating hemostasis, inflammation, and angiogenesis and their consequences on the pathogenesis of cardiovascular diseases, such as atherosclerosis, myocardial infarction, and venous thrombosis. Furthermore, new developments of the therapeutic potential of PMVs for the treatment of cardiovascular diseases will be discussed.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
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影响因子：
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作者：
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作者：
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影响因子：
11.1
作者：
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通讯作者：
Boilard, Eric