Sub-100nm gold nanomatryoshkas improve photo-thermal therapy efficacy in large and highly aggressive triple negative breast tumors.
Sub-100nm gold nanomatryoshkas improve photo-thermal therapy efficacy in large and highly aggressive triple negative breast tumors.
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DOI：
10.1016/j.jconrel.2014.07.038
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发表时间：
2014-10-10
期刊：
影响因子：
--
通讯作者：
Joshi A
中科院分区：
文献类型：
--
作者：
Ayala-Orozco C;Urban C;Bishnoi S;Urban A;Charron H;Mitchell T;Shea M;Nanda S;Schiff R;Halas N;Joshi A
对于用于治疗高度侵袭性癌症和大肿瘤的有效的近红外光热转换器存在未满足的需求，其中光的穿透可以显著减少，并且肿瘤内纳米颗粒运输由于缺氧或坏死区域的存在而受到限制。我们报告了亚100 nm金纳米matryushkas获得的性能优势，包括同心的金-硅-金层相比，传统的~150 nm硅核金纳米壳光热疗法的三阴性乳腺癌。我们证明，二氧化硅-核-金-壳纳米颗粒尺寸减少33%，同时保持近红外等离子体共振，并保持纳米颗粒表面电荷恒定，导致两种尺寸的相同剂量的注射金后，纳米颗粒的肿瘤积累为4至5倍。在相同的光热治疗条件下，nanomatryushka治疗组携带大（>1000 mm 3）和高侵袭性三阴性乳腺肿瘤的小鼠的存活时间加倍。nanomatryoshka的较高吸收横截面导致光子到热能转换的较高效率，并且与大肿瘤内的4-5X累积相结合导致上级治疗功效。
There is an unmet need for efficient near-infrared photothermal transducers for the treatment of highly aggressive cancers and large tumors where the penetration of light can be substantially reduced, and the intra-tumoral nanoparticle transport is restricted due to the presence of hypoxic or nectrotic regions. We report the performance advantages obtained by sub 100 nm gold nanomatryushkas, comprising of concentric gold-silica-gold layers compared to conventional ~150 nm silica core gold nanoshells for photothermal therapy of triple negative breast cancer. We demonstrate that a 33% reduction in silica-core-gold-shell nanoparticle size, while retaining near-infrared plasmon resonance, and keeping the nanoparticle surface charge constant, results in a four to five fold tumor accumulation of nanoparticles following equal dose of injected gold for both sizes. The survival time of mice bearing large (>1000 mm3) and highly aggressive triple negative breast tumors is doubled for the nanomatryushka treatment group under identical photo-thermal therapy conditions. The higher absorption cross-section of a nanomatryoshka results in a higher efficiency of photonic to thermal energy conversion and coupled with 4-5X accumulation within large tumors results in superior therapy efficacy.
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影响因子：
17.1
作者：
Leonov, Alexei P.;Zheng, Jiwen;Clogston, Jeffrey D.;Stern, Stephan T.;Patri, Anil K.;Wei, Alexander
通讯作者：
Wei, Alexander
影响因子：
3.9
作者：
Day, Emily S.;Thompson, Patrick A.;Zhang, Linna;Lewinski, Nastassja A.;Ahmed, Nabil;Drezek, Rebekah A.;Blaney, Susan M.;West, Jennifer L.
通讯作者：
West, Jennifer L.
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
3.7
作者：
Cole, Joseph R.;Mirin, Nikolay A.;Halas, Naomi J.
通讯作者：
Halas, Naomi J.
影响因子：
13.3
作者：
Gobin, Andre M.;Watkins, Emily M.;Quevedo, Elizabeth;Colvin, Vicki L.;West, Jennifer L.
通讯作者：
West, Jennifer L.