Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception†.
Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception†.
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DOI：
10.1093/biolre/ioaa075
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发表时间：
2020-08-04
影响因子：
3.6
通讯作者：
Winuthayanon W
中科院分区：
文献类型：
--
作者：
Anamthathmakula P;Winuthayanon W
精液液化是一种蛋白质水解过程，由于女性生殖道中前列腺衍生丝氨酸蛋白酶的酶活性，凝胶状的射精精液变得含水。液化过程对于精子获得活力和成功运输到输卵管（或动物的输卵管）中的受精部位至关重要。精液高粘稠或液化失败是男性不育的原因之一。因此，射精后女性生殖道丝氨酸蛋白酶的生化抑制是新型避孕药开发的主要目标。在这里，我们将讨论负责精液液化的射精中的蛋白质成分，以及过去涉及液化过程的避孕方法的任何发展。我们认为抑制精液液化有潜力发展成为一种非激素避孕方法。
Semen liquefaction is a proteolytic process where a gel-like ejaculated semen becomes watery due to the enzymatic activity of prostate-derived serine proteases in the female reproductive tract. The liquefaction process is crucial for the sperm to gain their motility and successful transport to the fertilization site in Fallopian tubes (or oviducts in animals). Hyperviscous semen or failure in liquefaction is one of the causes of male infertility. Therefore, the biochemical inhibition of serine proteases in the female reproductive tract after ejaculation is a prime target for novel contraceptive development. Herein, we will discuss protein components in the ejaculates responsible for semen liquefaction and any developments of contraceptive methods in the past that involve the liquefaction process. We propose inhibition of semen liquefaction has the potential to be developed as a non-hormonal contraceptive method.
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影响因子：
4.8
作者：
Emami, Nashmil;Diamandis, Eleftherios P.
通讯作者：
Diamandis, Eleftherios P.
DOI：
10.3109/01485019308988370
发表时间：
1993-01-01
期刊：
ARCHIVES OF ANDROLOGY
影响因子：
--
作者：
GONZALES, GF;KORTEBANI, G;MAZZOLLI, AB
通讯作者：
MAZZOLLI, AB
影响因子：
4.4
作者：
Edstrom, Anneli M. L.;Malm, Johan;Frohm, Birgitta;Martellini, Julie A.;Giwercman, Aleksander;Morgelin, Matthias;Cole, Alexander M.;Sorensen, Ole E.
通讯作者：
Sorensen, Ole E.
影响因子：
6.5
作者：
Brattsand, M;Stefansson, K;Egelrud, T
通讯作者：
Egelrud, T
影响因子：
3.7
作者：
Emami, Nashmil;Scorilas, Andreas;Diamandis, Eleftherios P.
通讯作者：
Diamandis, Eleftherios P.