CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin.
CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin.
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DOI：
10.1084/jem.194.10.1541
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发表时间：
2001-11-19
期刊：
影响因子：
--
通讯作者：
Butcher EC
中科院分区：
文献类型：
--
作者：
Reiss Y;Proudfoot AE;Power CA;Campbell JJ;Butcher EC
趋化因子胸腺和活化调节趋化因子（TARC; CCL 17）通过皮肤（但不是肠）小静脉展示，并且被认为触发循环皮肤归巢记忆T细胞的血管停滞，所述循环皮肤归巢记忆T细胞均匀地表达TARC受体CC趋化因子受体（CCR）4。由皮肤角质形成细胞表达的皮肤T细胞吸引趋化因子（CTACK; CCL 27）也吸引皮肤记忆T细胞，并且被假设也有助于淋巴细胞募集到皮肤。在这里，我们表明，慢性皮肤炎症诱导CD 4 T细胞表达E-选择素结合活性（皮肤归巢记忆细胞的标志物）在引流淋巴结，这些E-选择素配体+ T细胞有效地迁移到TARC和CTACK。在24小时体内归巢测定中，来自野生型小鼠或令人惊讶地来自CCR 4缺陷型供体的刺激的淋巴结T细胞有效地迁移到发炎的皮肤;并且抑制性抗CTACK抗体对野生型淋巴细胞募集没有影响。然而，用抗CTACK单克隆抗体抑制消除了CCR 4缺陷型T细胞的皮肤募集。我们的结论是CTACK和CCR 4都可以支持T细胞归巢到皮肤，并且其中一个或另一个是皮肤迟发型超敏反应中淋巴细胞募集所必需的。
The chemokine thymus and activation-regulated chemokine (TARC; CCL17) is displayed by cutaneous (but not intestinal) venules, and is thought to trigger vascular arrest of circulating skin homing memory T cells, which uniformly express the TARC receptor CC chemokine receptor (CCR)4. Cutaneous T cell–attracting chemokine (CTACK; CCL27), expressed by skin keratinocytes, also attracts cutaneous memory T cells, and is hypothesized to assist in lymphocyte recruitment to skin as well. Here we show that chronic cutaneous inflammation induces CD4 T cells expressing E-selectin binding activity (a marker of skin homing memory cells) in draining lymph node, and that these E-selectin ligand+ T cells migrate efficiently to TARC and to CTACK. In 24 h in vivo homing assays, stimulated lymph node T cells from wild-type mice or, surprisingly, from CCR4-deficient donors migrate efficiently to inflamed skin; and an inhibitory anti-CTACK antibody has no effect on wild-type lymphocyte recruitment. However, inhibition with anti-CTACK monoclonal antibody abrogates skin recruitment of CCR4-deficient T cells. We conclude that CTACK and CCR4 can both support homing of T cells to skin, and that either one or the other is required for lymphocyte recruitment in cutaneous delayed type hypersensitivity.
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影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
影响因子：
64.8
作者：
Austrup, F;Vestweber, D;Hamann, A
通讯作者：
Hamann, A
DOI：
10.1083/jcb.141.4.1053
发表时间：
1998-05-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Campbell JJ;Bowman EP;Murphy K;Youngman KR;Siani MA;Thompson DA;Wu L;Zlotnik A;Butcher EC
通讯作者：
Butcher EC
DOI：
10.1084/jem.193.9.1105
发表时间：
2001-05-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Baekkevold ES;Yamanaka T;Palframan RT;Carlsen HS;Reinholt FP;von Andrian UH;Brandtzaeg P;Haraldsen G
通讯作者：
Haraldsen G
影响因子：
15.3
作者：
Kunkel, E J;Campbell, J J;Haraldsen, G;Pan, J;Boisvert, J;Roberts, A I;Ebert, E C;Vierra, M A;Goodman, S B;Genovese, M C;Wardlaw, A J;Greenberg, H B;Parker, C M;Butcher, E C;Andrew, D P;Agace, W W
通讯作者：
Agace, W W