6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7.
6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3beta receptor CCR7.
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DOI：
10.1083/jcb.141.4.1053
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发表时间：
1998-05-18
期刊：
影响因子：
--
通讯作者：
Butcher EC
中科院分区：
文献类型：
--
作者：
Campbell JJ;Bowman EP;Murphy K;Youngman KR;Siani MA;Thompson DA;Wu L;Zlotnik A;Butcher EC
称为6-C-因子、次级淋巴组织趋化因子（SLC）、TCA 4或Exodus-2（本文称为6CK/SLC）的β趋化因子可以触发在生理剪切下滚动的淋巴细胞的快速整联蛋白依赖性停滞，并且由高内皮小静脉高度表达，高内皮小静脉是参与淋巴细胞从血液归巢到淋巴结和派尔集合淋巴结中的特化血管。我们发现，6CK/SLC是淋巴细胞趋化因子受体CCR 7（EBI-1，BLR-2）的激动剂，先前被描述为相关β趋化因子MIP-3β（ELC或Exodus-3）的受体。此外，6 CK/SLC和MIP-3β吸引相同的主要循环淋巴细胞群，包括初始和记忆T细胞> B细胞（但不包括自然杀伤细胞）;对MIP-3β的脱敏抑制淋巴细胞对6 CK/SLC的趋化性，但不抑制对α趋化因子SDF-1（基质细胞衍生因子）的趋化性; 6 CK/SLC竞争MIP-3β与静息小鼠淋巴细胞的结合。结果提示，大多数循环淋巴细胞对6CK/SLC和MIP-3β的反应主要是通过它们共同的受体CCR 7，这些分子可能是体内生理性淋巴细胞再循环的重要介质。
The β chemokine known as 6-C-kine, secondary lymphoid-tissue chemokine (SLC), TCA4, or Exodus-2 (herein referred to as 6CK/SLC) can trigger rapid integrin-dependent arrest of lymphocytes rolling under physiological shear and is highly expressed by high endothelial venules, specialized vessels involved in lymphocyte homing from the blood into lymph nodes and Peyer's patches. We show that 6CK/SLC is an agonist for the lymphocyte chemoattractant receptor, CCR7 (EBI-1, BLR-2), previously described as a receptor for the related β chemokine MIP-3β (ELC or Exodus-3). Moreover, 6CK/SLC and MIP-3β attract the same major populations of circulating lymphocytes, including naive and memory T cells > B cells (but not natural killer cells); desensitization to MIP-3β inhibits lymphocyte chemotaxis to 6CK/SLC but not to the α chemokine SDF-1 (stromal cell–derived factor); and 6CK/SLC competes for MIP-3β binding to resting mouse lymphocytes. The findings suggest that the majority of circulating lymphocytes respond to 6CK/SLC and MIP-3β in large part through their common receptor CCR7 and that these molecules may be important mediators of physiological lymphocyte recirculation in vivo.
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影响因子：
56.9
作者：
Campbell, JJ;Hedrick, J;Butcher, EC
通讯作者：
Butcher, EC
影响因子：
56.9
作者：
Butcher, EC;Picker, LJ
通讯作者：
Picker, LJ
DOI：
10.1084/jem.184.3.963
发表时间：
1996-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Loetscher M;Gerber B;Loetscher P;Jones SA;Piali L;Clark-Lewis I;Baggiolini M;Moser B
通讯作者：
Moser B
影响因子：
56.9
作者：
DAWSON, PE;MUIR, TW;KENT, SBH
通讯作者：
KENT, SBH
影响因子：
4.8
作者：
Nagira, M;Imai, T;Yoshie, O
通讯作者：
Yoshie, O