The relationship between executive functioning, processing speed, and white matter integrity in multiple sclerosis.
The relationship between executive functioning, processing speed, and white matter integrity in multiple sclerosis.
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DOI：
10.1080/13803395.2013.806649
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发表时间：
2013
影响因子：
2.2
通讯作者：
Wylie G
中科院分区：
文献类型：
--
作者：
Genova HM;DeLuca J;Chiaravalloti N;Wylie G
本研究的主要目的是探讨执行任务的表现和白色物质的完整性之间的关系，评估扩散张量成像（DTI）在多发性硬化症（MS）。第二个目的是研究处理速度如何影响执行功能和FA之间的关系。这种关系在两个严重依赖于处理速度的执行任务中进行了检查：颜色词干扰测试和线索制作测试（Delis-Kaplan执行功能系统）。据推测，减少分数各向异性（FA）与MS中执行任务的表现不佳有关，但这种关系会受到执行任务处理速度的统计校正的影响。15名健康对照者和25名MS患者参与了研究。回归分析被用来研究执行功能和FA之间的关系，无论是之前和之后的处理速度从执行分数。在处理速度从执行分数中删除之前，减少FA与包括胼胝体和上级纵束在内的弥散网络中的色词干扰测试和线索制作测试的不良表现相关。然而，一旦处理速度被删除，执行功能和FA之间的关系不再显着的连线测试，显着减少，更本地化的颜色词干扰测试。
The primary purpose of the current study was to examine the relationship between performance on executive tasks and white matter integrity, assessed by diffusion tensor imaging (DTI) in Multiple Sclerosis (MS). A second aim was to examine how processing speed affects the relationship between executive functioning and FA. This relationship was examined in two executive tasks that rely heavily on processing speed: the Color-Word Interference Test and Trail-Making Test (Delis-Kaplan Executive Function System). It was hypothesized that reduced fractional anisotropy (FA) is related to poor performance on executive tasks in MS, but that this relationship would be affected by the statistical correction of processing speed from the executive tasks. 15 healthy controls and 25 persons with MS participated. Regression analyses were used to examine the relationship between executive functioning and FA, both before and after processing speed was removed from the executive scores. Before processing speed was removed from the executive scores, reduced FA was associated with poor performance on Color-Word Interference Test and Trail-Making Test in a diffuse network including corpus callosum and superior longitudinal fasciculus. However, once processing speed was removed, the relationship between executive functions and FA was no longer significant on the Trail Making test, and significantly reduced and more localized on the Color-Word Interference Test.
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影响因子：
2.6
作者：
Drew, Margaret A.;Starkey, Nicola J.;Isler, Robert B.
通讯作者：
Isler, Robert B.
影响因子：
3.9
作者：
Benedict, RHB;Fischer, JS;Munschauer, F
通讯作者：
Munschauer, F
影响因子：
11.2
作者：
McDonald, WI;Compston, A;Wolinsky, JS
通讯作者：
Wolinsky, JS
DOI：
10.1196/annals.1340.039
发表时间：
2005-01-01
期刊：
WHITE MATTER IN COGNITIVE NEUROSCIENCE: ADVANCES IN DIFFUSION TENSOR IMAGING AND ITS APPLICATIONS
影响因子：
--
作者：
Ge, YL;Law, M;Grossman, RI
通讯作者：
Grossman, RI
影响因子：
9.9
作者：
Christodoulou, C;Krupp, LB;Peyster, R
通讯作者：
Peyster, R