Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection.
Simultaneously complete but not partial taste and smell losses were associated with SARS-CoV-2 infection.
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DOI：
10.1016/j.ijid.2021.03.083
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发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Prasithsirikul W
中科院分区：
文献类型：
--
作者：
Trachootham D;Thongyen S;Lam-Ubol A;Chotechuang N;Pongpirul W;Prasithsirikul W
本研究旨在探讨味觉缺失与严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)感染之间的关系，并阐明味觉偏好是否影响味觉缺失。对366名泰国患者进行了配对病例对照研究，其中122人经RT-PCR确诊为SARS-CoV-2阳性(病例组)，244人为SARS-CoV-2阴性(对照组)。味觉、嗅觉和食欲的变化通过自我报告的视觉模拟量表进行评估。对甜味、咸味、鲜味、酸味、苦味和辛辣的偏好使用验证的味觉-26问卷进行判断。两组患者均观察到味觉和嗅觉的部分丧失，而完全丧失(感觉障碍和嗅觉丧失)仅在病例组中检测到。此外，只有嗅觉障碍和嗅觉障碍与SARS-CoV-2阳性有关(P<；0.001，优势比分别为14.5%和27.5%)。在病例组中，味觉、嗅觉和食欲得分下降得更严重(P<；0.0001)。多因素分析显示，嗅觉障碍和嗅觉障碍是预测SARS-CoV-2阳性的最好因素，其次是食欲不振和发热。同时丧失味觉和嗅觉而不是味觉偏好与SARS-CoV-2阳性有关(P<；0.01，优势比2.28)。味觉和嗅觉完全丧失，但不是部分丧失，是SARS-CoV-2感染的最好预测指标。在目前的新冠肺炎大流行期间，健康人群中突然同时完全丧失味觉和嗅觉的人应该进行新冠肺炎筛查。
The aim of this study was to investigate the association between taste and smell losses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and to elucidate whether taste preference influences such taste loss. A matched case–control study was conducted in 366 Thai participants, including 122 who were confirmed SARS-CoV-2-positive by RT-PCR (case group) and 244 who were SARS-CoV-2-negative (control group). Taste, smell, and appetite changes were assessed by self-reported visual analog scale. Preference for sweet, salty, umami, sour, bitter, and spicy were judged using the validated TASTE-26 questionnaire. Partial taste and smell losses were observed in both groups, while complete losses (ageusia and anosmia) were detected only in the case group. Moreover, only ageusia and anosmia were associated with SARS-CoV-2 positivity (P < 0.001, odds ratio of 14.5 and 27.5, respectively). Taste, smell, and appetite scores were more severely reduced in the case group (P < 0.0001). Multivariate analysis showed that anosmia and ageusia were the best predictors of SARS-CoV-2 positivity, followed by appetite loss and fever. Simultaneous losses of taste and smell but not taste preferences were associated with SARS-CoV-2 positivity (P < 0.01, odds ratio 2.28). Complete, but not partial, losses of taste and smell were the best predictors of SARS-CoV-2 infection. During the current COVID-19 pandemic, healthy persons with sudden simultaneous complete loss of taste and smell should be screened for COVID-19.
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