The Wistar Kyoto Rat: A Model of Depression Traits.
The Wistar Kyoto Rat: A Model of Depression Traits.
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DOI：
10.2174/1570159x21666221129120902
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发表时间：
2023
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
关于动物研究在精神病学中的价值，人们正在进行辩论，有效的推理方式表明，与人类精神疾病相比，单个动物模型的局限性。人类抑郁症不是一种同质性疾病；因此，人们不能指望单一的动物模型反映抑郁症的异质性。这篇有限的综述提出的论点是，Wistar京都(WKY)大鼠表现出内在的抑郁特征。WKY的表型并不完全反映人类抑郁症的表型，但清楚地表明了它的共同特征。与其他常规使用的近交系或近交系大鼠相比，WKY表现出绝望样的行为，被动地应对压力，共病焦虑，以及更多的药物使用。识别这些表型的常用测试反映了探索性、逃避导向和戒断样行为。WKY总是在新的环境中选择退出或回避，并在这些测试中选择冻结行为来回应挑战。在WKY中，对压力环境的生理反应被夸大了。选择性育种产生了两个WKY亚株，它们的基因几乎相同，但表现出明显的行为差异，包括抑郁症样行为。WKY及其亚型可能具有抑郁个体亚群的特征，包括社交退缩、低能量、体重减轻、睡眠障碍和特定认知功能障碍。WKY和WKY亚株的基因组包含变异，这些变异影响了最近的人类抑郁症遗传学研究中发现的许多基因的功能。因此，这些品系的大鼠在表型和遗传水平上都具有人类抑郁症的特征，使它们成为抑郁症特征的模型。
There is an ongoing debate about the value of animal research in psychiatry with valid lines of reasoning stating the limits of individual animal models compared to human psychiatric illnesses. Human depression is not a homogenous disorder; therefore, one cannot expect a single animal model to reflect depression heterogeneity. This limited review presents arguments that the Wistar Kyoto (WKY) rats show intrinsic depression traits. The phenotypes of WKY do not completely mirror those of human depression but clearly indicate characteristics that are common with it. WKYs present despair-like behavior, passive coping with stress, comorbid anxiety, and enhanced drug use compared to other routinely used inbred or outbred strains of rats. The commonly used tests identifying these phenotypes reflect exploratory, escape-oriented, and withdrawal-like behaviors. The WKYs consistently choose withdrawal or avoidance in novel environments and freezing behaviors in response to a challenge in these tests. The physiological response to a stressful environment is exaggerated in WKYs. Selective breeding generated two WKY substrains that are nearly isogenic but show clear behavioral differences, including that of depression-like behavior. WKY and its substrains may share characteristics of subgroups of depressed individuals with social withdrawal, low energy, weight loss, sleep disturbances, and specific cognitive dysfunction. The genomes of the WKY and WKY substrains contain variations that impact the function of many genes identified in recent human genetic studies of depression. Thus, these strains of rats share characteristics of human depression at both phenotypic and genetic levels, making them a model of depression traits.
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作者：
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DOI：
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发表时间：
2020
期刊：
Alzheimer's & dementia (Amsterdam, Netherlands)
影响因子：
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通讯作者：
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